{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:58:36Z","timestamp":1772506716765,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,2,3]]},"abstract":"<jats:p>We present the case of a 42-year-old man with AIDS who had lost complete vision of his left eye for the past 15\u2005days. MRI and brightness scan ultrasonography were performed on his eyes that suggested of endophthalmitis with dendritic involvement in the left eye. Viral DNA PCR was performed in aqueous humour sample that confirmed the presence of herpes simplex virus and showed a negative result for cytomegalovirus. The patient was treated with a high dose of oral acyclovir for 10\u2005days and long-term topical acyclovir. Neodymium-doped yttrium aluminum garnet procedure was performed to clear up the cornea, and intraocular pressure was controlled with brimonidine and timolol maleate. The patient was diagnosed to have disseminated tuberculosis (tuberculoma of the brain) and was started with antituberculosis therapy. His condition improved significantly after the treatment, and keratitis in cornea started to clean up.<\/jats:p>","DOI":"10.1136\/bcr-2013-202804","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T06:45:52Z","timestamp":1393483552000},"page":"bcr2013202804","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Herpes simplex keratitis-induced endophthalmitis in a patient with AIDS with disseminated tuberculosis"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ajit","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanav","family":"Khera","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabih","family":"Inam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Manjunath","family":"Hande","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Kasturba Medical College, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.1","first-page":"377","article-title":"Clinical profile of HIV in India","volume":"121","author":"Kumarasamy","year":"2005","journal-title":"Indian J Med Res"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2008.44.1.36"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.3","unstructured":"National AIDS Control Organization. Directory of HIV data. http:\/\/naco.gov.in\/NACO\/Quick_Links\/Directory_of_HIV_Data\/ (accessed 2 Nov 2013)."},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.4","unstructured":"World Health Organization. Scaling up antiretroviral therapy in resource-limited settings: treatment guidelines for a public health approach, 2003 revision. Geneva: WHO, 2004."},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.5","unstructured":"Nlm.nih.gov. Disseminated tuberculosis: MedlinePlus Medical Encyclopedia. [Online]. http:\/\/www.nlm.nih.gov\/medlineplus\/ency\/article\/000624.htm (accessed 1 Nov 2013)."},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.6","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.102622"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.7","first-page":"9","article-title":"Tuberculoma of brain","volume":"13","author":"Kumar","year":"2011","journal-title":"Pulmon"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.8","first-page":"256","article-title":"Magnetic resonance imaging in central nervous system tuberculosis","volume":"19","author":"Trivedi","year":"2009","journal-title":"Indian J RadiolImaging"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.9","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90079-S"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.10","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.5.613"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32658-3"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70614-6"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.026"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.14","first-page":"233","article-title":"Blepharitis and lid ulcer as initial ocular manifestation in acquired immunodeficiency syndome patients","volume":"45","author":"Biswas","year":"1997","journal-title":"Indian J Ophthalmol"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.15","first-page":"195","article-title":"Bilateral frosted branch angiitis and cytomegalovirus retinitis in acquired immunodeficiency syndrome","volume":"47","author":"Biswas","year":"1999","journal-title":"Indian J Ophthalmol"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.16","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.42412"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2006.05.001"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.18","doi-asserted-by":"publisher","DOI":"10.1159\/000027516"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.19","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199903000-00002"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2147\/OPTH.S19087","article-title":"A novel educational tool for teaching ocular ultrasound","volume":"5","author":"Mustafa","year":"2011","journal-title":"Clin Ophthalmol"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.21","unstructured":"Waldron RG . B-scan ocular ultrasound. http:\/\/emedicine.medscape.com\/article\/1228865-overview (accessed 2 Nov 2013)."},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.22","first-page":"31","article-title":"Role of B-scan ultrasonography in pre-operative cataract patients","volume":"4","author":"Qureshi","year":"2010","journal-title":"Int J Health Sci"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.23","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-198706040-00011"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.24","doi-asserted-by":"crossref","unstructured":"Vadlapudi A Vadlapatla R Earla R . Novel biotinylated lipid prodrugs of acyclovir for the treatment of herpetic keratitis (HK): transporter recognition, tissue stability and antiviral activity. Pharma Res 2013:1 14.","DOI":"10.1007\/s11095-013-1059-7"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.25","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.379"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2147\/OPTH.S8666","article-title":"Topical ganciclovir in the treatment of acute herpetic keratitis","volume":"4","author":"Tabbara","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.27","first-page":"225","article-title":"First-line treatment for elevated intraocular pressure (IOP) associated with open-angle glaucoma or ocular hypertension: focus on bimatoprost","volume":"1","author":"Law","year":"2007","journal-title":"Clin Ophthalmol"},{"key":"2025082804094460000_2014.feb27_1.bcr2013202804.28","doi-asserted-by":"crossref","first-page":"pii: bcr2012007942","DOI":"10.1136\/bcr-2012-007942","article-title":"Concomitant herpes simplex virus and cytomegalovirus endotheliitis in immunocompetent patient","volume":"2013","author":"Kasetsuwan","year":"2013","journal-title":"BMJ Case Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-202804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:09:54Z","timestamp":1756379394000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-202804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":28,"alternative-id":["10.1136\/bcr-2013-202804"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-202804","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,27]]}}}