{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:40:05Z","timestamp":1756377605229,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Radiation retinopathy is a delayed-onset side effect of radiation exposure caused by retinal ischaemia that may induce proliferative retinopathy with neovascularisation, vitreous haemorrhage and macular oedema. An otherwise healthy, 51-year-old male patient who had been diagnosed with olfactory neuroblastoma and undergone complete surgical removal of the lesion followed by cranial irradiation developed bilateral cataracts and radiation retinopathy. The patient was treated by panretinal photocoagulation (PRP), followed by three-port pars-plana vitrectomy. Recurrent episodes of vitreous haemorrhages occurred following surgery and the patient was successfully treated by one intravitreal injection of bevacizumab with resolution of vitreous blood. Vitreous haemorrhage recurred 6\u2005months later and a scheduled treatment with intravitreal bevacizumab every 4\u2005months was established, preventing further haemorrhagic episodes. Six months after the last injection, a new episode of vitreous haemorrhage occurred.<\/jats:p>\n               <jats:p>Scheduled intravitreal bevacizumab injections may help prevent recurrent vitreous haemorrhages in vitrectomised patients with radiation retinopathy.<\/jats:p>","DOI":"10.1136\/bcr-2013-203177","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T06:07:22Z","timestamp":1391753242000},"page":"bcr2013203177","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Bevacizumab in vitreous haemorrhage secondary to radiation retinopathy"],"prefix":"10.1136","volume":"2014","author":[{"given":"Javier Antonio","family":"Montero","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Pio del Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Yanez-Castro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pio del Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"Sanchis-Merino","sequence":"additional","affiliation":[{"name":"Allergy Unit, Pio del Rio Hortega University Hospital, Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Maria","family":"Ruiz-Moreno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Castilla La Mancha, Albacete, Albacete, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34611-4"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.2","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2010.500299"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.3","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328329b62d"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.4","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200510000-00009"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.5","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31816b3192"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.018"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.7","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90347-6"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00055735-199706000-00005","article-title":"Clinical implications of vascular growth factors in proliferative retinopathies","volume":"8","author":"Aiello","year":"1997","journal-title":"Curr Opin Ophthalmol"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.11.045"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.10","doi-asserted-by":"publisher","DOI":"10.3129\/i08-171"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01101.x"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01632.x"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.13","first-page":"1130","article-title":"Effect of intraocular surgery and ketamine on aqueous and serum cytokines","volume":"13","author":"Tu","year":"2007","journal-title":"Mol Vis"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.14","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.087403"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182340cc1"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0002-9394(88)90237-1","article-title":"Photocoagulation treatment of radiation retinopathy","volume":"105","author":"Kinyoun","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01021.x"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01821.x"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.19","first-page":"200","article-title":"[Neovascularization from the scleral wound as the cause of vitreous rebleeding after vitrectomy for proliferative diabetic retinopathy]","volume":"102","author":"Sawa","year":"1998","journal-title":"Nihon Ganka Gakkai Zasshi"},{"key":"2025082803114611000_2014.feb06_2.bcr2013203177.20","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4140"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-203177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:11:53Z","timestamp":1756375913000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-203177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":20,"alternative-id":["10.1136\/bcr-2013-203177"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-203177","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,2,7]]}}}