{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:40:34Z","timestamp":1783615234784,"version":"3.55.0"},"reference-count":30,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,7,14]]},"abstract":"<jats:p>Adenoid cystic carcinoma (ACC) is a rare type of cancer that typically originates in the salivary glands. Surgical removal can lead to functional loss and psychological distress. <jats:italic>Viscum album<\/jats:italic> extract (VAE) is a herbal remedy with dose-dependent cytotoxic, apoptogenic and immunological effects. In some case reports, tumour regression has been observed following high-dose local applications of VAE. An active 88-year-old man with fast-growing ACC of the hard palate refused surgical removal and received high-dose intratumoural injections of VAE (alone) over a 10-month period. The tumour decreased in size, softened and loosened from its surroundings. A biopsy during the course showed inflammation. The patient remained well and without functional limitations during the therapy and follow-up period (5\u2005months). VAE produced no reported side effects. This aged patient exemplifies a satisfying course of ACC under VAE resulting in good quality of life and partial tumour regression.<\/jats:p>","DOI":"10.1136\/bcr-2013-203180","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T08:12:54Z","timestamp":1406794374000},"page":"bcr2013203180","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Tumour response following high-dose intratumoural application of <i>Viscum album<\/i> on a patient with adenoid cystic carcinoma"],"prefix":"10.1136","volume":"2014","author":[{"given":"Paul Georg","family":"Werthmann","sequence":"first","affiliation":[{"name":"Institute for Applied Epistemology and Medical Methodology at the University of Witten\/Herdecke, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Helling","sequence":"additional","affiliation":[{"name":"Medical Practice for General Medicine, Koblenz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Heusser","sequence":"additional","affiliation":[{"name":"Faculty of Health, Chair of Theory of Medicine, Integrative and Anthroposophic Medicine, Institute of Integrative Medicine, University of Witten\/Herdecke, Herdecke, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunver Sophia","family":"Kienle","sequence":"additional","affiliation":[{"name":"Institute for Applied Epistemology and Medical Methodology at the University of Witten\/Herdecke, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,7,31]]},"reference":[{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.10.016"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.2","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200404000-00013"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940515)73:10<2563::AID-CNCR2820731018>3.0.CO;2-X"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.090969"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21042"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.6","unstructured":"Kaufman J . A guide to systemic therapy for patients with progressive adenoid cystic carcinoma. Adenoid Cystic Carcinoma Research Foundation, 2010."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.7","unstructured":"O'Regan B Hirshberg C . Spontaneous remission\u2014an annonted bibliography. Institute of Noetic Sciences, 1993."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.2.289"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.9","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi110"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.10","first-page":"103","article-title":"Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts","volume":"12","author":"Kienle","year":"2007","journal-title":"Eur J Med Res"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.11","unstructured":"Kienle GS Kiene H . Die Mistel in der Onkologie\u2014Fakten und konzeptionelle Grundlagen. Stuttgart, New York: Schattauer Verlag, 2003."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.12","unstructured":"B\u00fcssing A , ed. Mistletoe. The genus Viscum. Amsterdam: Hardwood Academic Publishers, 2000."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.13","doi-asserted-by":"publisher","DOI":"10.1177\/1534735410369673"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.043"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.15","unstructured":"Scheffler A Mast H Fischer S . Komplette Remission eines Mundh\u00f6hlenkarzinoms nach alleiniger Mistelbehandlung. In: Scheer R Becker H Berg PA , eds. Grundlagen der Misteltherapie. Aktueller Stand der Forschung und klinische Anwendung. Stuttgart: Hippokrates Verlag GmbH, 1996:453\u201366."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.eujim.2009.08.010","article-title":"Durable tumour responses following primary high-dose induction with mistletoe extracts: two case reports","volume":"1","author":"Orange","year":"2010","journal-title":"Eur J Integr Med"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7453\/gahmj.2012.1.1.006","article-title":"Durable regression of primary cutaneous B-cell lymphoma following fever-inducing mistletoe treatment\u2014two case reports","volume":"1","author":"Orange","year":"2012","journal-title":"Glob Adv Health Med"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.11.001"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.19","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-72"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.20","first-page":"603","article-title":"The CARE guidelines: consensus-based clinical case reporting guideline development","volume":"110","author":"Gagnier","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.21","unstructured":"Ya-Juan L Hong-Lan Z . Inhibitory effect of mistletoe alkali on adenoid cystic carcinoma cells. J Jilin Univ 2008 ;34:601\u20134."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.22","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.3892\/or.2013.2732","article-title":"Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines","volume":"30","author":"Klingbeil","year":"2013","journal-title":"Oncol Rep"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-005-1318-y"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.24","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-79"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.25","first-page":"1","article-title":"[The mistletoe preparation ISOREL in the treatment of laryngeal cancer\u2014case report of a complete remission] Das Mistelpr\u00e4parat ISOREL bei Larynxkarzinom\u2014Fallbericht von einer Totalremission","volume":"1982","author":"Geir","year":"1982","journal-title":"Krebsgeschehen"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.26","unstructured":"Orange M Lace A von Laue B . The importance of the primary dosage in mistletoe therapy. In: Scheer R Alban S Becker H Holzgrabe U Kemper FH Kreis W ., eds. Die Mistel in der Tumortherapie 2. Essen: KVC Verlag, 2009:385\u2013400."},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2011.03.009"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.28","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21458"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.29","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90007-5"},{"key":"2025082802035884000_2014.jul31_1.bcr2013203180.30","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-102"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-203180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:04:11Z","timestamp":1756371851000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-203180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":30,"alternative-id":["10.1136\/bcr-2013-203180"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-203180","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}