{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:06:10Z","timestamp":1782601570563,"version":"3.54.5"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,6,16]]},"abstract":"<jats:p>An otherwise healthy young man presented with gradual progressive fatigue for the past 12\u2005months disturbing his daily activities. Clinical examination revealed marked generalised muscular hypertrophy including the temporalis muscles bilaterally. Investigation revealed that the patient was grossly hypothyroid due to Hashimoto's thyroiditis with rhabdomyolysis and acute kidney injury. The finding of muscle weakness and pseudohypertrophy in association with hypothyroidism is called Hoffman\u2019s syndrome. The patient was hydrated and thyroxine replacement initiated. On follow-up, the patient showed clinical as well as biochemical improvement.<\/jats:p>","DOI":"10.1136\/bcr-2013-203269","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T06:48:18Z","timestamp":1404456498000},"page":"bcr2013203269","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Hashimoto's thyroiditis presenting as Hoffman's syndrome, rhabdomyolysis and acute kidney injury"],"prefix":"10.1136","volume":"2014","author":[{"given":"Gasim Salaheldin","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Musa","family":"Zaid","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manus","family":"Moloney","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Limerick Hospital Nenagh, Nenagh, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"2025082701022788000_2014.jul04_1.bcr2013203269.1","unstructured":"Werner SC Ingbar SH Braverman LE . Werner and Ingbar's the thyroid: a fundamental and clinical text. 9th edn. Philadelphia: Lippincott Williams and Wilkins, 2005:894\u20135."},{"key":"2025082701022788000_2014.jul04_1.bcr2013203269.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70186-9"},{"key":"2025082701022788000_2014.jul04_1.bcr2013203269.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70176-6"},{"key":"2025082701022788000_2014.jul04_1.bcr2013203269.4","first-page":"41","article-title":"Hypothyroidism presenting as Hoffman's syndrome","volume":"102","author":"Deepak","year":"2004","journal-title":"J Indian Med Assoc"},{"key":"2025082701022788000_2014.jul04_1.bcr2013203269.5","first-page":"332","article-title":"Hoffmann syndrome: presentation in hypothyroidism","volume":"51","author":"Udayakumar","year":"2005","journal-title":"J Postgrad Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-203269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:02:38Z","timestamp":1756281758000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-203269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,4]]},"references-count":5,"alternative-id":["10.1136\/bcr-2013-203269"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-203269","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,4]]}}}