{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:03:50Z","timestamp":1762409030809,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,5,8]]},"abstract":"<jats:p>The simultaneous occurrence of hyperthyroidism and hyperparathyroidism was previously reported to be rare, but it was recognised more and more clearly by effective evaluations. Recent studies also mentioned the coexistence of parathyroid adenoma and papillary thyroid carcinoma (PTC). The potential mechanism is still unknown. We report a case of a 46-year-old man coexisted with primary hyperparathyroidism, Graves\u2019 hyperthyroidism and occult PTC. The patient had a 6-month history of polyphagia and irritability. Blood examinations showed elevated serum calcium and parathyroid hormone levels. Serum phosphate was lower. Thyroid function evaluation indicted Graves\u2019 hyperthyroidism. Ultrasound showed a solitary hyperchoic thyroid nodule in the right gland. Parathyroid radioisotope scanning found a mild enhancement of 99mTc absorption in the lower part of the right parathyroid gland. A surgical exploration was carried out and the parathyroid adenoma resection was performed. An occult micro-PTC with BRAF<jats:sup>V600E<\/jats:sup> mutation was also detected.<\/jats:p>","DOI":"10.1136\/bcr-2013-203436","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T07:01:08Z","timestamp":1401433268000},"page":"bcr2013203436","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Incidental finding of papillary thyroid carcinoma with BRAF<sup>V600E<\/sup> mutation in a patient with coexistent primary hyperparathyroidism and Graves\u2019 hyperthyroidism"],"prefix":"10.1136","volume":"2014","author":[{"given":"Yayi","family":"He","sequence":"first","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,30]]},"reference":[{"key":"2025082803025315000_2014.may30_2.bcr2013203436.1","first-page":"105","article-title":"Primary hyperparathyroidism and coexisting hyperthyroidism\u2014review of the literature","volume":"43","author":"Lam","year":"1989","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1212115"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20366"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.09.012"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.5","doi-asserted-by":"publisher","DOI":"10.4174\/jkss.2011.81.5.316"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.6","first-page":"56","article-title":"Incidental finding of bilateral papillary thyroid carcinoma in a patient with primary hyperparathyroidism","volume":"13","author":"Alavi","year":"2010","journal-title":"Hell J Nucl Med"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00015458.2004.11679616","article-title":"Coexistent thyroid pathologies and high rate of papillary cancer in patients with primary hyperparathyroidism: controversies about minimal invasive parathyroid surgery","volume":"104","author":"K\u00f6sem","year":"2004","journal-title":"Acta Chir Belg"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.8","doi-asserted-by":"publisher","DOI":"10.4158\/EP09138.OR"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.9","first-page":"116","article-title":"Prognostic significance of aberrant gene methylation in gastric cancer","volume":"2","author":"Shi","year":"2012","journal-title":"Am J Cancer Res"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03293.x"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.11","first-page":"103","article-title":"Parathyroid adenoma Localization","volume":"26","author":"Nasiri","year":"2012","journal-title":"Med J Islam Repub Iran"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.12","first-page":"371","article-title":"Accuracy and consistency of fine-needle aspiration biopsy in the diagnosis and management of solitary thyroidnodules","volume":"7","author":"Kessler","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.13","first-page":"939","article-title":"Concomitant Graves\u2019 disease and primary hyperparathyroidism: the first case report in mainland of China and literature review","volume":"115","author":"Xiao","year":"2002","journal-title":"Chin Med J (Engl)"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.14","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.1999.0880"},{"key":"2025082803025315000_2014.may30_2.bcr2013203436.15","first-page":"883","article-title":"Papillary parathyroid adenoma. 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