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MRI of the brain revealed asymmetrical parieto-occipital volume loss and genetic testing demonstrated a pathogenic expansion of the chromosome 9 open reading frame 72 (<jats:italic>C9ORF72<\/jats:italic>) gene consistent with familial frontotemporal dementia caused by a hexanucleotide repeat expansion at <jats:italic>C9ORF72<\/jats:italic>, a recently discovered cause of familial frontotemporal dementia\/motor neuron disease. This form of frontotemporal dementia should be considered as an important potential differential diagnosis for patients presenting with psychotic symptoms in later life, in whom a detailed family history and thorough cognitive assessment is essential.<\/jats:p>","DOI":"10.1136\/bcr-2013-203458","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T09:21:19Z","timestamp":1402651279000},"page":"bcr2013203458","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Neurodegenerative disorder masquerading as psychosis in a forensic psychiatry setting"],"prefix":"10.1136","volume":"2014","author":[{"given":"Andrew","family":"Sommerlad","sequence":"first","affiliation":[{"name":"Division of Psychiatry, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Lee","sequence":"additional","affiliation":[{"name":"Camden and Islington NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Warren","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, University College London Hospitals, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jagp.2013.01.051","article-title":"Psychosis of Alzheimers disease: prevalence, incidence, persistence, risk factors, mortality","volume":"11","author":"Vilalta-Franch","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2022"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0128-7"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr355"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182684634"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318268452e"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr361"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr353"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303507"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550070129021"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.13","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.146"},{"key":"2025082804275826000_2014.jun13_1.bcr2013203458.14","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt145"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2013-203458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:28:07Z","timestamp":1756380487000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2013-203458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,13]]},"references-count":14,"alternative-id":["10.1136\/bcr-2013-203458"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2013-203458","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,6,13]]}}}