{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:07:48Z","timestamp":1767704868412,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,4,20]]},"abstract":"<jats:p>We describe the development of tubulointerstitial nephritis after starting clozapine therapy in a patient with treatment-resistant schizophrenia. A 54-year-old mixed-race patient with a longstanding history of paranoid schizophrenia was started on the antipsychotic clozapine. Two months after starting clozapine he developed fevers, cough and acute renal failure which initially responded to 7\u2005days of prednisolone but recurred after completing the steroid course. Renal biopsy confirmed acute tubulointerstitial nephritis and he was started on a course of steroids with renal recovery in 72\u2005h. Clozapine was later stopped. This case highlights a serious and potential life-threatening complication of an important antipsychotic used in treatment-resistant schizophrenia.<\/jats:p>","DOI":"10.1136\/bcr-2013-203502","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T02:33:15Z","timestamp":1400639595000},"page":"bcr2013203502","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Clozapine induced tubulointerstitial nephritis in a patient with paranoid schizophrenia"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ravi","family":"Parekh","sequence":"first","affiliation":[{"name":"Imperial College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zozik","family":"Fattah","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, UCLH, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilraj","family":"Sahota","sequence":"additional","affiliation":[{"name":"Central Middlesex Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernie","family":"Colaco","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Central Middlesex Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"2025082803075176000_2014.may20_1.bcr2013203502.1","unstructured":"NICE. 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