{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:05Z","timestamp":1756363205874,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,3,17]]},"abstract":"<jats:p>A 74-year-old man was previously diagnosed with BCR-ABL1-positive pre-B cell acute lymphoblastic leukaemia (pre-B ALL) based on bone marrow cytology, flow cytometry, cytogenetics and fluorescent in situ hybridisation findings. Following a highly complicated hospital course, the patient achieved cytogenetic remission by consolidated chemotherapy and the tyrosine kinase inhibitor dasatinib. He subsequently presented with relapsed pre-B ALL after 3\u2005years in remission. In consideration of his challenging clinical history, he was started on concurrent ponatinib (45\u2005mg daily) and bortezomib (1.3\u2005mg\/m<jats:sup>2<\/jats:sup> intravenous weekly). The major molecular response was achieved (&lt;0.0893% BCR-ABL1 transcripts) after 3\u2005months. Bone marrow now demonstrates a BCR-ABL1-negative, complete cytogenetic response. The patient continues to do well with mild thrombocytopenia and improved anaemia on bortezomib and 30\u2005mg daily ponatinib. Our experience with a single patient suggests the feasibility of combined targeted therapy with ponatinib and bortezomib. This novel treatment approach achieved clinical remission with a manageable toxicity profile.<\/jats:p>","DOI":"10.1136\/bcr-2014-203894","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T07:18:05Z","timestamp":1397287085000},"page":"bcr2014203894","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Haematological complete remission by ponatinib and bortezomib in a patient with relapsed, Ph<sup>+<\/sup> pre-B acute lymphoblastic leukaemia"],"prefix":"10.1136","volume":"2014","author":[{"given":"Sara","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Levy","sequence":"additional","affiliation":[{"name":"Innovative Clinical Trials Center, Baylor Sammons Cancer Center, Dallas, Texas, 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