{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:56:24Z","timestamp":1771577784549,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,4,9]]},"abstract":"<jats:p>A 41-year-old man presented with postcervical traumatic complete quadriparesis under intrathecal baclofen therapy (ITB) for refractory spasticity. Less than 24\u2005h after having his baclofen pump substituted, he develops hyperthermia, seizures, cognitive depression, acute hypoxaemic respiratory failure and cardiovascular instability leading to mechanical ventilation and vasopressor support. He was transferred to an intensive care unit with diagnosis of community-acquired pneumonia leading to septic shock. He evolved with progressive clinical worsening and multisystem organ failure and cardiac arrest in non-shockable rhythm (pulseless electrical activity)\u20144\u2005min resuscitation with return of spontaneous circulation. Considering the possible diagnosis of baclofen withdrawal syndrome and, in suspicion of ITB delivery disruption, the catheter system was surgically explored and a leaking tubule attachment was found. Despite aggressive cardiovascular, respiratory and renal support therapy, clinical improvement occurred only after restoration of intrathecal drug delivery. He was discharged from the hospital after 56\u2005days, having returned to baseline status.<\/jats:p>","DOI":"10.1136\/bcr-2014-204322","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T10:49:45Z","timestamp":1400064585000},"page":"bcr2014204322","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac arrest due to baclofen withdrawal syndrome"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ana Lu\u00edsa","family":"Cardoso","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Centro Hospitalar do Porto EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Quintaneiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine of Hospital Distrital da Figueira da Foz EPE, Figueira da Foz, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Seabra","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Centro Hospitalar do Porto EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Unidade de Cuidados Intensivos Polivalente do Centro Hospitalar do Porto EPE, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"2025082803223901000_2014.may14_1.bcr2014204322.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03422.x"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968308328724"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.3","doi-asserted-by":"crossref","first-page":"575168","DOI":"10.5402\/2012\/575168","article-title":"Complications of intrathecal baclofen pump: prevention and cure","volume":"2012","author":"Awaad","year":"2012","journal-title":"ISRN Neurol"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/ner.12010","article-title":"Rate of complications among the recipients of intrathecal baclofen pump in Japan: a multicenter study","volume":"16","author":"Taira","year":"2012","journal-title":"Neuromodulation"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.5","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.32820"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(99)90337-4"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.7","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162200001055"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(03)00039-8"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.9","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e318188a952"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.10","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199809000-00011"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0120-3347(12)70033-3"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.12","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.112"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.13","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9422-6"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-002-0634-8"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199211000-00034"},{"key":"2025082803223901000_2014.may14_1.bcr2014204322.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1277-9"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-204322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:22:49Z","timestamp":1756376569000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-204322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":16,"alternative-id":["10.1136\/bcr-2014-204322"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-204322","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}