{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T10:55:43Z","timestamp":1759056943625,"version":"3.40.4"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,5,8]]},"abstract":"<jats:p>Beh\u00e7et's disease (BD) is a chronic inflammatory disorder that involves the parenchymal central nervous system (neuro-BD, NBD) approximately in 5\u201349% of patients, causing lesions rarely located in the spinal cord (SC). We report the first case of NBD-myelitis treated with intravenous rituximab. A 41-year-old man affected by BD presented with mild paraparesis with a miliary involvement and a \u2018net-like\u2019 gadolinium enhancement (Gde) of the SC. After a therapeutic attempt with pulsed cyclophosphamide and intravenous methylprednisolone, the clinical and neuroradiological course worsened. A progressive improvement was observed after rituximab administration associated with low doses of oral prednisone. No disease activity was detected and the patient reported no adverse event. After six rituximab cycles, cervical MRI was normal while thoracic MRI showed a slight T2\u2013weighted hyperintensity of D4\u2013D10 spinal tract without Gde. A combined use of rituximab and oral steroids resulted in a long-term suppression of NBD activity without any safety concern.<\/jats:p>","DOI":"10.1136\/bcr-2014-204366","type":"journal-article","created":{"date-parts":[[2014,5,30]],"date-time":"2014-05-30T11:01:08Z","timestamp":1401447668000},"page":"bcr2014204366","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of myelitis in Beh\u00e7et's disease with rituximab"],"prefix":"10.1136","volume":"2014","author":[{"given":"Maria Jos\u00e8","family":"Messina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariaemma","family":"Rodegher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Scotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,30]]},"reference":[{"key":"2025042705311922000_2014.may30_2.bcr2014204366.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.11.2183"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.3","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050205"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70015-8"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.5","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0436"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01754.x"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.7","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050329"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.8","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050579"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1673.2000.00783.x"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2175"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-008-0057-9"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.12","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00200"},{"key":"2025042705311922000_2014.may30_2.bcr2014204366.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032534"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-204366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:31:26Z","timestamp":1745757086000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-204366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,30]]},"references-count":13,"alternative-id":["10.1136\/bcr-2014-204366"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-204366","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,5,30]]}}}