{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:30Z","timestamp":1756425750299,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,4,4]]},"abstract":"<jats:p>We report a case of a 69-year-old man who started dual antiplatelet therapy (APT) with aspirin and clopidogrel after recent implantation of drug-eluting coronary stent and developed massive bleeding due to large duodenal gastrointestinal stromal tumour (GIST). Following endoscopic haemostasis and discontinuation of dual APT, neoadjuvant chemotherapy with imatinib was started under continuation of \u2018single\u2019 APT with aspirin. A good chemotherapeutic response was achieved without recurrence of bleeding, and subsequent less invasive surgical resection of the tumour was performed, while preoperative single APT was continued for prevention of stent thrombosis. The patient recovered well without any thromboembolic or bleeding events. Neoadjuvant imatinib therapy and subsequent less invasive surgery under continuation of APT is one of the preferred approaches for patients with duodenal GIST with severe thromboembolic comorbidities, as in the current case.<\/jats:p>","DOI":"10.1136\/bcr-2014-204462","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T09:07:52Z","timestamp":1398676072000},"page":"bcr2014204462","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Successful treatment of bleeding large duodenal gastrointestinal stromal tumour in a patient under dual antiplatelet therapy after recent drug-eluting coronary stent implantation"],"prefix":"10.1136","volume":"2014","author":[{"given":"Keita","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Department of Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kuramitsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kokura Memorial Hospital, Kitakyushu, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1432-8"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.2","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v5.i2.16"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.003"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.4","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.123545"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.5","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21164"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.057"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.08.005"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.6004\/jnccn.2012.0099","article-title":"Soft tissue sarcoma, version 2.2012: featured updates to the NCCN guidelines","volume":"10","author":"von Mehren","year":"2012","journal-title":"J Natl Compr Can Netw"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-72"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.11","doi-asserted-by":"crossref","unstructured":"\u00c5hl\u00e9n J Westerdahl J Zedenius J . Side-effects from imatinib treatment of advanced GIST\u2013associated with a better outcome. Journal of Cancer Therapeutics and Research 2012;1. doi:http:\/\/dx.doi.org\/10.7243\/2049-7962-1-11","DOI":"10.7243\/2049-7962-1-11"},{"key":"2025082723234564000_2014.apr28_2.bcr2014204462.12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-29"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-204462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:23:56Z","timestamp":1756362236000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-204462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":12,"alternative-id":["10.1136\/bcr-2014-204462"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-204462","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,4,28]]}}}