{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:35:21Z","timestamp":1782797721260,"version":"3.54.5"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,6,6]]},"abstract":"<jats:p>A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms\u2019 tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examination were normal. A nerve conduction velocity study which was performed on the peripheral nerves revealed predominant motor polyneuropathy compatible with axonal loss involving the upper limbs. The patient had received a cumulative vincristine dose of 17\u2005mg\/m<jats:sup>2<\/jats:sup> before developing esotropia. Vincristine-induced abducens nerve mononeuropathy and subclinical motor polyneuropathy was suspected. Unilateral esotropia markedly improved after the discontinuation of vincristine and a short course of oral pyridoxine treatment.<\/jats:p>","DOI":"10.1136\/bcr-2014-204524","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T07:08:11Z","timestamp":1403680091000},"page":"bcr2014204524","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Vincristine-induced polyneuropathy in a child with stage I Wilms\u2019 tumour presenting with unilateral abducens nerve palsy"],"prefix":"10.1136","volume":"2014","author":[{"given":"Panadeekarn","family":"Panjawatanan","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimlak","family":"Charoenkwan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamornwan","family":"Katanyuwong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worawut","family":"Choeyprasert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"2025082707201032000_2014.jun25_1.bcr2014204524.1","first-page":"2212","article-title":"Mechanism of inhibition of cell proliferation by vinca alkaloids","volume":"51","author":"Jordan","year":"1991","journal-title":"Cancer Res"},{"key":"2025082707201032000_2014.jun25_1.bcr2014204524.2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4281"},{"key":"2025082707201032000_2014.jun25_1.bcr2014204524.3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/BF03259853","article-title":"Vincristine neurotoxicity. 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