{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:11:17Z","timestamp":1773486677359,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,8,5]]},"abstract":"<jats:p>We report two cases of chronic myeloid leukaemia (CML) with extreme thrombocytosis. The first patient was a 65-year-old man who presented with prolonged history of upper abdominal discomfort, anorexia and two episodes of recent gum bleeds without fever or other bleeding manifestations. He was a chronic smoker with no other comorbidities. Examination revealed moderate hepatosplenomegaly. On investigation, he was found to have extreme thrombocytosis (3\u2005500\u2005000\/mm<jats:sup>3<\/jats:sup>) and leucocytosis with moderate anaemia. In view of the leucocytosis, he was investigated for CML and found to be positive for BCR-ABL by reverse transcription PCR (RT-PCR). He received imatinib 400\u2005mg\/day and achieved complete haematological response at the end of 3\u2005months. The second patient was a 7-year-old boy who presented with fever, cough and cold of 2-week duration. Examination revealed mild hepatomegaly with palpable spleen tip. Haemogram and peripheral smear revealed moderate leucocytosis with extreme thrombocytosis (2\u2005800\u2005000\/mm<jats:sup>3<\/jats:sup>). On evaluation, he was found to be BCR-ABL positive and responded well to imatinib treatment. In both these cases, massive thrombocytosis was an unusual presentation of a well-known entity, namely, CML. This degree of thrombocytosis is usually seen only in essential thrombocytosis.<\/jats:p>","DOI":"10.1136\/bcr-2014-204564","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T10:56:02Z","timestamp":1439981762000},"page":"bcr2014204564","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic myeloid leukaemia with extreme thrombocytosis"],"prefix":"10.1136","volume":"2015","author":[{"given":"Shailendra Prasad","family":"Verma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunkumar","family":"Subbiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajini Elizabeth","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debdatta","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.1","first-page":"235","article-title":"Clinico-pathological profile of chronic myeloid leukemia","volume":"20","author":"Jameel","year":"2006","journal-title":"JPMI"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.2","first-page":"458716","article-title":"Chronic myeloid leukemia with e19a2 BCR-ABL1 transcripts and marked thrombocytosis: the role of molecular monitoring.","volume":";2012","author":"Langabeer","year":"2012","journal-title":"Case Rep Hematol"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1798.x"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.4","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2012.47.1.7"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.5","first-page":"247","article-title":"Chronic myeloid leukemia onset with marked thrombocythemia","volume":"14","author":"Shen","year":"2006","journal-title":"Zhonqquo Shi Yan Xue Ye Xue Za Zhi"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20257"},{"key":"2025042706584523000_2015.aug19_1.bcr2014204564.7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s00277-004-0877-4","article-title":"Philadelphia(Ph) chromosome positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood: natural history and diagnostic differentiation from Ph-negative essential thrombocythemia","volume":"83","author":"Michiels","year":"2004","journal-title":"Ann Hematol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-204564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:58:55Z","timestamp":1745762335000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-204564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":7,"alternative-id":["10.1136\/bcr-2014-204564"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-204564","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}