{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:36:24Z","timestamp":1761708984110,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,5,25]]},"abstract":"<jats:p>Primary non-seminomatous germ cell tumours of anterior mediastinum are uncommon. Endodermal sinus tumour of the anterior mediastinum (yolk sac) is a rare but lethal neoplasm. We present a case of an 18-year-old man who presented with chest pain, cough and haemosputum with markedly raised serum \u03b1-fetoprotein (AFP) levels above 112\u2005000\u2005ng\/mL. Chest roentgenogram and CT showed a giant anterior mediastinal mass. CT guided biopsy revealed a diagnosis of endodermal sinus tumour. After the completion of chemotherapy, extensive surgical resection was carried out along with the right lung metastastectomy. Five years postresection follow-up the patient is disease free with normal serum tumour markers. This is the longest survival ever reported of such tumours with highest AFP level (&gt;112\u2005000\u2005ng\/mL) and lung metastasis.<\/jats:p>","DOI":"10.1136\/bcr-2014-204662","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T12:26:15Z","timestamp":1403007975000},"page":"bcr2014204662","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Radical surgical resection for giant primary mediastinal endodermal sinus tumour with pulmonary metastasis after chemotherapy: can be curative"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ikram Ulhaq","family":"Chaudhry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Rahhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imtiaz","family":"Khurshid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Mutairi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1699-0463.1967.tb01290.x","article-title":"Primary germ cell tumor of the anterior mediastinum with features of endodermal sinus tumor (mesoblastoma vitellinum)","volume":"70","author":"Teilmann","year":"1967","journal-title":"Acta Pathol Microbiol Scand"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.1.54"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.079"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.4","unstructured":"Teilum G . Endodermal sinus tumor. In: Special tumors of the ovary and testis and related extragonadal lesions: comparative pathology and histological identification. Copenhagen: Munksgaard, 1971:33\u201374."},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970815)80:4<681::AID-CNCR6>3.0.CO;2-Q"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.6","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1200\/JCO.2000.18.6.1181","article-title":"Results of treatment after relapse from high dose chemotherapy in germ cell tumors","volume":"18","author":"Porcu","year":"2000","journal-title":"J Clin Oncol"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01472-1"},{"key":"2025042705501230000_2014.jun17_1.bcr2014204662.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70015-2"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-204662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:50:20Z","timestamp":1745758220000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-204662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":8,"alternative-id":["10.1136\/bcr-2014-204662"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-204662","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,6,17]]}}}