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Treatment with prednisolone, azathioprine or methotrexate failed to adequately control all symptoms in the long term. In the absence of a specific and well-established therapy for MRS, treatment with adalimumab was administered. Under adalimumab, total remission of all symptoms was achieved, indicating that tumour necrosis factor-\u03b1 blockers are a promising therapeutic option for patients with Melkersson-Rosenthal syndrome.<\/jats:p>","DOI":"10.1136\/bcr-2014-204674","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T14:49:45Z","timestamp":1400078985000},"page":"bcr2014204674","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["An extraordinary form of the Melkersson-Rosenthal syndrome successfully treated with the tumour necrosis factor-\u03b1 blocker adalimumab"],"prefix":"10.1136","volume":"2014","author":[{"given":"Juergen","family":"Stein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Paulke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Schacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Noehte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"2025042703382786000_2014.may14_1.bcr2014204674.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.t01-1-00056.x"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181f04912"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00353.x"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.4","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90387-5"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.5","doi-asserted-by":"publisher","DOI":"10.1007\/s100060050021"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-39431"},{"key":"2025042703382786000_2014.may14_1.bcr2014204674.7","unstructured":"Orphanet. 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