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Dyskeratosis congenita is an inherited disorder that causes shortening or dysfunction of telomeres, affecting mainly rapidly dividing cells (particularly in the skin and haematopoietic system). It leads to bone marrow failure, combined immunodeficiency and predisposition to cancer. The confirmation of this diagnosis allows genetic counselling and medical monitoring of these patients, in order to detect early complications such as bone marrow aplasia or malignancies.<\/jats:p>","DOI":"10.1136\/bcr-2014-204714","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T11:48:10Z","timestamp":1402573690000},"page":"bcr2014204714","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Pneumococcal vaccine failure: Can it be a primary 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