{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:57:14Z","timestamp":1778943434230,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,21]]},"abstract":"<jats:p>Terbinafine is a commonly prescribed antifungal agent used in the treatment oftrichophytic onychomycosis and chronic cutaneous mycosis that are resistant to other treatments. This case report highlights a rarely documented but important adverse hepatic reaction that was caused by the use of oral terbinafine. A woman in her thirties presented with a 3-week history of jaundice, malaise, itching, nausea, decreased appetite, weight loss, dark orange urine and intermittent non-radiating epigastric pain. She had recently finished a 3-week course of oral terbinafine for a fungal nail infection. Liver biopsy findings were consistent with chronic active hepatitis secondary to a drug reaction. A few days after initial presentation, the patient developed erythema nodosum. Delayed development of erythema nodosum secondary to terbinafine could not be excluded.<\/jats:p>","DOI":"10.1136\/bcr-2014-205331","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T07:52:10Z","timestamp":1417765930000},"page":"bcr2014205331","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["A curious case of cholestasis: oral terbinafine associated with cholestatic jaundice and subsequent erythema nodosum"],"prefix":"10.1136","volume":"2014","author":[{"given":"Kartik","family":"Kumar","sequence":"first","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gill","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Shafei","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine L","family":"Wright","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.1","first-page":"357","article-title":"Colestatic toxic hepatitis caused by terbinafine: case report","volume":"24","author":"Burstein","year":"2004","journal-title":"Rev Gastroenterol Peru"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018870828038"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.3","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21034"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.4","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200109000-00021"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00459.x"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80273-X"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.7","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i3.133"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.8","doi-asserted-by":"publisher","DOI":"10.1021\/tx0002029"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200305000-00008"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.10","first-page":"113","article-title":"Drug-induced cholestasis","volume":"12","author":"Chitturi","year":"2001","journal-title":"Semin Gastrointest Dis"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00729.x"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1440-1746.2011.06746.x","article-title":"Relationships between blood levels of fat soluble vitamins and disease aetiology and severity in adults awaiting liver transplantation","volume":"26","author":"Abbott-Johnson","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00007611-197701000-00014","article-title":"Erythema nodosum in patients with tinea pedis and onychomycosis","volume":"70","author":"Hicks","year":"1977","journal-title":"South Med J"},{"key":"2025082703394066000_2014.dec05_1.bcr2014205331.14","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651994000600006"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-205331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:39:50Z","timestamp":1756291190000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-205331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":14,"alternative-id":["10.1136\/bcr-2014-205331"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-205331","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}