{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:22:25Z","timestamp":1762017745668,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,7,17]]},"abstract":"<jats:p>We report the case of a 30-year-old woman, without any previous comorbidities presenting with acute onset headache, altered sensorium and unsteadiness of gait. Neurological evaluation revealed a drowsy patient with papilloedema, bilateral lateral rectus palsy, generalised hyper-reflexia and up going plantar responses. Urgent imaging performed showed extensive cortical venous sinus thrombosis. Workup for secondary causes of cortical venous sinus thrombosis revealed very high titres of antinuclear antibody and anti-dsDNA, but negative antiphospholipid antibodies (APLA). In hospital she started developing other complications of systemic lupus erythematosus (SLE). Urine evaluation revealed proteinuria and granular casts suggestive of glomerulonephritis. Cardiac evaluation revealed moderate pericardial effusion. We have discussed neurolupus as initial presentation of SLE and the rare occurrence of major neurovascular complications without secondary APLA syndrome.<\/jats:p>","DOI":"10.1136\/bcr-2014-205355","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T06:35:33Z","timestamp":1406702133000},"page":"bcr2014205355","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral venous thrombosis presenting with subdural haematoma as first presentation for systemic lupus erythematosus with negative antiphospholipid antibodies"],"prefix":"10.1136","volume":"2014","author":[{"given":"Ayman","family":"Alboudi","sequence":"first","affiliation":[{"name":"Department of Neurology, Rashid Hospital, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pournamy","family":"Sarathchandran","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rashid Hospital, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Alrukn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rashid Hospital, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abubaker","family":"Al Madani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rashid Hospital, Dubai, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.8.1226"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200216"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.3","first-page":"30","article-title":"Servicio de Neurolog\u00eda, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. Cerebral venous thrombosis as the presenting symptom of systemic lupus erythematosus","volume":"39","author":"Cardona-Portela","year":"2004","journal-title":"Rev Neurol"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.4","first-page":"365","article-title":"[Cerebral venous thrombosis in systemic lupus erythematosus. Case report and literature review]","volume":"44","author":"Agreda-V\u00e1squez","year":"2006","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.STR.0000254476.05620.14","article-title":"Baseline disease activity, hyperlipidemia, and hypertension are predictive factors for ischemic stroke and stroke severity in systemic lupus erythematosus","volume":"8","author":"Mikdashi","year":"2007","journal-title":"Stroke"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00335-X"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109869"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/ajcp\/77.3.275","article-title":"Prekallikrein inhibition associated with the lupus anticoagulant","volume":"77","author":"Sanfelippo","year":"1982","journal-title":"Am J Clin Pathol"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0307-742X(21)00606-8","article-title":"Antiphospholipid anti-bodies","volume":"11","author":"Harris","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1055\/s-0038-1661628","article-title":"IgG binding to endothelial cells in systemic lupus erythematosus","volume":"56","author":"LeRoux","year":"1986","journal-title":"Thromb Haemost"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.11","first-page":"123","article-title":"Prevalence and prognosis of cerebrovascular accidents and its subtypes among patients with systemic lupus erythematosus in Isfahan, Iran: a hospital clinic-based study","volume":"5","author":"Saadatnia","year":"2014","journal-title":"Int J Prev Med"},{"key":"2025082804083586000_2014.jul30_1.bcr2014205355.12","doi-asserted-by":"publisher","DOI":"10.1159\/000047635"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-205355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:08:43Z","timestamp":1756379323000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-205355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":12,"alternative-id":["10.1136\/bcr-2014-205355"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-205355","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}