{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:08:42Z","timestamp":1778951322556,"version":"3.51.4"},"reference-count":29,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,5]]},"abstract":"<jats:p>Cancer-associated retinopathy (CAR) is one of the paraneoplastic neurological syndromes and characterised by retinal degeneration. Autoimmunity between cancer cells and retinal proteins is considered a major cause of CAR. The presence of serum autoantibodies to retinal antigens plays an important role in the diagnosis. A 60-year-old man reporting of visual disturbance and paresthaesia of extremities presented to our hospital. CT scan revealed a massive tumour in the left lower lobe of the lung. Small cell lung cancer was diagnosed histologically with bronchoscopy. Ophthalmological examination showed retinopathy but not optic neuritis. Anti-CV2\/collapsin response mediator protein (CRMP)-5 and anti-Hu antibodies were detected by further serum examination. It has been reported that anti-CV2\/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis. This is the first case of CAR with presence of anti-CV2\/CRMP5 antibodies without neuritis.<\/jats:p>","DOI":"10.1136\/bcr-2014-205888","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T11:28:04Z","timestamp":1416828484000},"page":"bcr2014205888","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Small cell lung cancer and progressive 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