{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:43:49Z","timestamp":1777347829859,"version":"3.51.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,12,18]]},"abstract":"<jats:p>A 57-year-old man with type II mixed cryoglobulinaemia presented to the emergency department with a history of worsening lethargy, malaise and non-drenching night sweats in a relapsing\u2013remitting pattern. He was diagnosed with type II mixed cryoglobulinaemia 7\u2005months ago following episodes of fever, night sweats, lethargy and malaise associated with a non-blanching, purpuric, raised erythematous rash that responded partially to immunosuppressive therapy and short courses of oral antibiotics. A single blood culture then yielded<jats:italic>Granulicatella adiacens<\/jats:italic>which was reported as a possible contaminant and therefore, not pursued. Despite numerous other investigations, the underlying cause of his type II cryoglobulinaemia remained undetermined. On his current presentation, the physical examination revealed signs of infective endocarditis. Two further blood cultures grew<jats:italic>G. adiacens.<\/jats:italic>The diagnosis of infective endocarditis was established on a transoesophageal echocardiography, and the subsequent antibiotic and surgical therapy resulted in complete remission of his type II mixed cryoglobulinaemia<jats:italic>.<\/jats:italic><\/jats:p>","DOI":"10.1136\/bcr-2014-206091","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T18:49:13Z","timestamp":1420656553000},"page":"bcr2014206091","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Granulicatella adiacens<\/i>subacute bacterial endocarditis as the underlying cause of type II mixed cryoglobulinaemia"],"prefix":"10.1136","volume":"2015","author":[{"given":"Benjamin W C","family":"Sim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray Mun","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,1,7]]},"reference":[{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60242-0"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.039693-0"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2013.06.014"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.177-207.2001"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000165658.82869.17"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.6","doi-asserted-by":"publisher","DOI":"10.1067\/mhl.2003.2"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90852-3"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.8","first-page":"131","article-title":"Cryoglobulinaemia in patients with infectious endocarditis","volume":"19","author":"Hurwitz","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"2025042702131692000_2015.jan07_1.bcr2014206091.9","first-page":"489","article-title":"Cold precipitable serum globulins (\u2018cold fractions, cryoglobulins\u2019) in subacute bacterial endocarditis","volume":"40","author":"Dreyfuss","year":"1952","journal-title":"J Lab Clin Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-206091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:13:27Z","timestamp":1745745207000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-206091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,7]]},"references-count":9,"alternative-id":["10.1136\/bcr-2014-206091"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-206091","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,7]]}}}