{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:25:06Z","timestamp":1793381106647,"version":"4.5.0"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,2,26]]},"abstract":"<jats:p>Hepatoid adenocarcinoma (HAC) is a rare extrahepatic adenocarcinoma that morphologically and immunophenotypically mimics hepatocellular carcinoma (HCC). We report the case of a 42-year-old woman with an extensive cancer history who presented with right-sided abdominal pain and lower gastrointestinal (GI) bleeding, and was ultimately diagnosed with colon adenocarcinoma. She underwent sigmoidectomy and adjuvant chemotherapy. Approximately 1\u2005month after completion of chemotherapy, positron emission tomography showed presence of a 1.8\u2005cm\u00d71.4\u2005cm mesenteric lymph node. She underwent treatment with chemotherapy and radiation followed by lymph node resection. Pathological findings from the lymph node were consistent with poorly differentiated carcinoma with hepatocellular differentiation. When compared with pathology from the colonic resection, both specimens showed histomorphological features and immunohistochemical profiles consistent with hepatocellular differentiation. Given these findings, a diagnosis of HAC of the colon with metastasis to a mesenteric lymph node was made.<\/jats:p>","DOI":"10.1136\/bcr-2014-206222","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T14:14:04Z","timestamp":1429193644000},"page":"bcr2014206222","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatoid adenocarcinoma of the colon"],"prefix":"10.1136","volume":"2015","author":[{"given":"Avan","family":"Armaghani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Hernandez","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Daily","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, University of Florida, Gainesville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.1","first-page":"539","article-title":"Rectal hepatoid carcinoma with liver metastases in a patient affected by ulcerative colitis","volume":"7","author":"Borgonovo","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02715.x"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237252"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.4","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-011-9424-5"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.5","doi-asserted-by":"publisher","DOI":"10.1159\/000305717"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.6","first-page":"1277","article-title":"[Existence of alpha feto protein during gastric-origin secondary cancer of the liver]","volume":"78","author":"Bourreille","year":"1970","journal-title":"La Presse medicale"},{"key":"2025082707294638000_2015.apr16_1.bcr2014206222.7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i3.321"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-206222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:29:55Z","timestamp":1756304995000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-206222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":7,"alternative-id":["10.1136\/bcr-2014-206222"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-206222","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]}}}