{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:14:32Z","timestamp":1791962072523,"version":"4.3.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,12,15]]},"abstract":"<jats:p>Persistent hyperplastic primary vitreous (PHPV) is an ocular developmental disorder resulting from incomplete apoptosis of the embryonic hyaloid vasculature. Unilateral PHPV is traditionally associated with a poor prognosis because of the challenges associated with managing progressive anisometropic amblyopia. We report a child with unilateral PHPV who underwent cataract extraction, primary posterior capsulotomy with anterior vitrectomy and intraocular lens implantation followed by combined trabeculectomy\/trabeculotomy within the first 8\u2005weeks of life. Intensive optometric and orthoptic input was required for many years to manage the increasing anisometropic amblyopia with final visual acuity of 20\/40 unaided in the affected eye and without evidence of glaucomatous optic neuropathy. This case illustrates the excellent visual outcome possible in a child with complex, unilateral PHPV using an intensive management approach comprising: early surgical intervention for congenital cataract and secondary glaucoma, meticulous monitoring of refraction, visual acuity and intraocular pressure and motivated parents who engaged in the management.<\/jats:p>","DOI":"10.1136\/bcr-2014-206525","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T03:28:38Z","timestamp":1420687718000},"page":"bcr2014206525","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Unilateral persistent hyperplastic primary vitreous: intensive management approach with excellent outcome beyond visual maturation"],"prefix":"10.1136","volume":"2015","author":[{"given":"Imran H","family":"Yusuf","sequence":"first","affiliation":[{"name":"Oxford Eye Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan Kantibhai","family":"Patel","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Salmon","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90066-0"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.053595"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.062"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.4","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2002.121324"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.9.1190"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jaapos.2011.06.004","article-title":"Infant Aphakia Treatment Study: effects of persistent fetal vasculature on outcome at 1year of age","volume":"15","author":"Morrison","year":"2010","journal-title":"J AAPOS"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.7","doi-asserted-by":"publisher","DOI":"10.1080\/09273970600701242"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00973-7"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.5664\/jcsm.2908","article-title":"Blue-light-blocking intraocular lens implantation improves the sleep quality of cataract patients","volume":"9","author":"Wei","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.10","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304024"},{"key":"2025082801010442000_2015.jan06_1.bcr2014206525.11","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.117887"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-206525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:01:12Z","timestamp":1756368072000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-206525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,6]]},"references-count":11,"alternative-id":["10.1136\/bcr-2014-206525"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-206525","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,6]]}}}