{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:09:00Z","timestamp":1762430940455,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,9,23]]},"abstract":"<jats:p>Isaacs\u2019 syndrome is a rare neuromuscular disorder of continuous muscle fibre activity resulting from peripheral nerve hyperexcitability. Symptoms commonly include myokymia (muscle twitching at rest), pseudomyotonia (delayed muscle relaxation), muscle cramps and stiffness. It is caused by voltage-gated potassium channel dysfunction and may be inherited or acquired. Treatment commonly includes anticonvulsants, immunosuppressive therapy and plasma exchange. To date only two cases of Isaacs\u2019 syndrome in pregnancy have been reported. We present a case of maternal Isaacs\u2019 along with a review of the literature. There are few reports of Isaacs\u2019 syndrome in pregnancy, but all are associated with favourable outcomes. Given the autosomal dominant inheritance pattern, genetic counselling of the gravida is recommended. Anticonvulsant may have to be used in pregnancy, and given the potential teratogenicity with several of these agents; preference should be given to newer drugs such as lamotrigine.<\/jats:p>","DOI":"10.1136\/bcr-2014-206704","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T14:34:34Z","timestamp":1412865274000},"page":"bcr2014206704","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Isaacs\u2019 syndrome in pregnancy"],"prefix":"10.1136","volume":"2014","author":[{"given":"Brianna","family":"Lide","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Haeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,10,9]]},"reference":[{"key":"2025042706411889000_2014.oct09_1.bcr2014206704.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.03.008"},{"key":"2025042706411889000_2014.oct09_1.bcr2014206704.2","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0b013e318246197d"},{"key":"2025042706411889000_2014.oct09_1.bcr2014206704.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.09.014"},{"key":"2025042706411889000_2014.oct09_1.bcr2014206704.4","first-page":"1311","article-title":"Acquired neuromyotonia heralding recurrent thymoma in myasthenia gravis","volume":"70","author":"Fleisher","year":"2013","journal-title":"JAMA Neurol"},{"key":"2025042706411889000_2014.oct09_1.bcr2014206704.5","doi-asserted-by":"crossref","unstructured":"Vernino S . Chapter 14: peripheral nerve hyperexcitability and the neuromuscular junction. In: Engel A , ed. Handbook of clinical neurology. 91st edn. 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