{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:40:08Z","timestamp":1745764808673,"version":"3.40.4"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,2]]},"abstract":"<jats:p>Neonatal Graves\u2019 disease is a rare disorder seen in 1 in 25\u2005000 births and in 1% of the offspring of mothers with either established or cured Graves\u2019 disease. This is due to transplacental passage of thyroid-stimulating immunoglobulins (TSIs). A higher TSI titre in maternal serum makes hyperthyroidism more likely in the fetus or newborn; however, not all fetuses born by women with positive TSIs develop overt hyperthyroidism. In spite of its rarity, its serious nature (if not treated) and its association with multisystem abnormalities justifies careful clinical screening and management. We report a preterm 30\u2005weeks neonate with neonatal thyrotoxicosis secondary to untreated maternal Graves\u2019 disease who, in addition to the typical hyperthyroidism symptoms, had unusual metabolic associations of neonatal cholestasis and hyperammonaemia. The patient was treated accordingly with a good response. This report supports previous reports on the association between neonatal hyperthyroidism and cholestatic liver disease. However, it is the second case report to describe the unusual association of hyperammonaemia and neonatal Graves\u2019 disease.<\/jats:p>","DOI":"10.1136\/bcr-2014-206725","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T11:28:04Z","timestamp":1416828484000},"page":"bcr2014206725","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal Graves\u2019 disease with unusual metabolic association from presentation to resolution"],"prefix":"10.1136","volume":"2014","author":[{"given":"Manal Mustafa","family":"Khadora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al Dubayee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0608-2"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.2","first-page":"122","article-title":"Prenatal treatment of thyrotoxicosis to prevent intrauterine growth retardation","volume":"60","author":"Check","year":"1982","journal-title":"Obstet Gynecol"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.727"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.4","doi-asserted-by":"publisher","DOI":"10.1159\/000092454"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.5","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-5-1036"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.6","unstructured":"Mejias-Heredia A , Litchfield WR , Zurakowski D . Assessing the risk of neonatal Graves disease using TSI measurements (abstract P3). 77th Meeting of the Endocrine Society 1995:460."},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.7","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.1171"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.8","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.6.426.428"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.9","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318228f9a8"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.10","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.5.476"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(59)80154-2"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.12","unstructured":"Potter EL , Craig JM . Pathology of the Fetus and the Infant. 3rd edn. Chicago: Year Book Medical Publishers, 1975:411."},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999957"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.14","first-page":"H302","article-title":"Induced fetal hyperthyroidism: cardiac output and oxygen consumption","volume":"239","author":"Lorijn","year":"1980","journal-title":"Am J Physiol"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211687"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340210052013"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3244"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030665"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.19","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199708000-00014"},{"key":"2025042707003174000_2014.nov24_1.bcr2014206725.20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2128"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-206725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:00:39Z","timestamp":1745762439000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-206725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":20,"alternative-id":["10.1136\/bcr-2014-206725"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-206725","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,11,24]]}}}