{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:10:09Z","timestamp":1745763009734,"version":"3.40.4"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,10,21]]},"abstract":"<jats:p>A 17-year-old girl was admitted to our unit with weight loss, dyspnoea, arthralgia and sinusitis. Her medical history was noteworthy for bronchial asthma and she required systemic steroid therapy. Her mother had a history of eosinophilic granulomatosis with polyangiitis (EGPA). Laboratory tests revealed excessive eosinophilia and elevated erythrocyte sedimentation. The assay for peripheral antineutrophil cytoplasmic antibodies was negative. Histopathological examination of lung biopsy revealed EGPA. The patient was treated with methylpredinosolone; her eosinophil count normalised and she began to improve clinically and radiographically. There is no genetic factor to influence susceptibility to this disease. To the best of our knowledge, this is the second report of familial EGPA disease in the literature, with a mother and daughter both being affected. EGPA disease should be kept in mind in a patient with uncontrolled asthma and eosinophilia with a positive family history for EGPA.<\/jats:p>","DOI":"10.1136\/bcr-2014-206934","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T15:02:31Z","timestamp":1415026951000},"page":"bcr2014206934","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Familial eosinophilic granulomatosis with polyangiitis in a mother and daughter"],"prefix":"10.1136","volume":"2014","author":[{"given":"Koray","family":"Harmanci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulya","family":"Anil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulkadir","family":"Kocak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ener Cagri","family":"Dinleyici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-1208"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.3","first-page":"277","article-title":"Allergic granulomatosis, allergic angiitis, and periarteritis nodosa","volume":"27","author":"Churg","year":"1951","journal-title":"Am J Pathol"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00005792-198403000-00001","article-title":"Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome","volume":"63","author":"Lanham","year":"1984","journal-title":"Medicine (Baltimore)"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.5","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199901000-00003"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.6","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-190"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-9-200511010-00006"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.8","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.857582"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.22834"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70371-9"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.11","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199801000-00002"},{"key":"2025042706515566000_2014.nov03_1.bcr2014206934.12","first-page":"618","article-title":"Familial vasculitides: Churg-Strauss syndrome and Wegener's granulomatosis in 2 first-degree relatives","volume":"30","author":"Manganelli","year":"2003","journal-title":"J Rheumatol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-206934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:52:03Z","timestamp":1745761923000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-206934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":12,"alternative-id":["10.1136\/bcr-2014-206934"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-206934","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}