{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:58:08Z","timestamp":1755223088952,"version":"3.43.0"},"reference-count":32,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,4,18]]},"abstract":"<jats:p>A 76-year-old woman was admitted to hospital from the rheumatology outpatient clinic for investigation of fatigue, malaise, emotional lability, muscle weakness, productive cough and postural hypotension. She had been taking prednisone 60\u201340\u2005mg daily for 6\u2005weeks for suspected giant cell arteritis, along with six other regular medications, and had recently finished a course of antibiotics. During her admission she underwent many investigations (mostly negative) and treatments (largely harmful). When the diagnosis of adverse drug reaction was eventually reached, her medications were withdrawn and her symptoms gradually resolved. She was discharged home 1\u2005month after admission, vowing never to return following her \u2018stormy course\u2019. Adverse drug reactions are a common cause of avoidable hospital admissions in the elderly, estimated to cost billions every year. The single greatest risk factor for adverse drug reactions is the number of medications a person takes. Deprescribing to reduce potentially inappropriate medication is a possible way forward.<\/jats:p>","DOI":"10.1136\/bcr-2014-207152","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T10:54:52Z","timestamp":1431600892000},"page":"bcr2014207152","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["No medicine is sometimes the best medicine"],"prefix":"10.1136","volume":"2015","author":[{"given":"Katharine Ann","family":"Wallis","sequence":"first","affiliation":[{"name":"Department of General Practice and Primary Health Care, University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"2025081104401820000_2015.may14_1.bcr2014207152.1","unstructured":"Hippocrates. Epidemics, Book I, Sect XI. In: Hippocrates, with an English translation by WHS Jones, 1923\u20131988. Loeb classical library. Cambridge, Mass: Harvard University Press, 165."},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1103053"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs.2010.047696"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.4","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzs015"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.5","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P627"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.6","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L037"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02698.x"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.8","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H658"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7456.15"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1316-4"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.11","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200321090-00002"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002574"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.13","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.2.4"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61091-5"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.16","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00422"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.17","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13153"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.18","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199914020-00005"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.19","unstructured":"NHS Scotland. Polypharmacy guidance. 2012. http:\/\/www.central.knowledge.scot.nhs.uk\/upload\/Polypharmacy%20full%20guidance%20v2.pdf (accessed 10 Nov 2014)."},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5694\/mja13.00200","article-title":"The benefits and harms of deprescribing","volume":"201","author":"Reeve","year":"2014","journal-title":"Med J Aust"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-13-56"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.22","doi-asserted-by":"crossref","unstructured":"Heath I . Role of fear in overdiagnosis and overtreatment\u2014an essay by Iona Heath. BMJ 2014;349. doi:10.1136\/bmj.g5176","DOI":"10.1136\/bmj.g5176"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.23","unstructured":"Wallis KA . Under a system of no-fault compensation for medical injury, is fear as a driver of over-diagnosis diminished? Preventing overdiagnosis: winding back the harms of too much medicine. Oxford, UK, 2014."},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.24","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.1662"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.25","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0106-8"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.26","doi-asserted-by":"crossref","unstructured":"Patterson SM , Cadogan CA , Kerse N , et al . Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev 2014 (10):CD008165.","DOI":"10.1002\/14651858.CD008165.pub3"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.27","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2004.012153"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.28","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181ef9a7e"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.29","first-page":"68","article-title":"Knowing how to stop: ceasing prescribing when the medicine is no longer required","volume":"18","author":"Ostini","year":"2012","journal-title":"J Manag Care Pharm"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.30","doi-asserted-by":"publisher","DOI":"10.2165\/0002512-200825120-00004"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.31","doi-asserted-by":"crossref","unstructured":"Le Conteur DG , Banks E , Gnjidic D , et al . Deprescribing. Aus Prescriber 2011;34:182\u20135.","DOI":"10.18773\/austprescr.2011.095"},{"key":"2025081104401820000_2015.may14_1.bcr2014207152.32","doi-asserted-by":"crossref","unstructured":"O'Mahony D , O'Sullivan D , Byrne S , et al . STOPP\/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 2014:44(2):213\u20138.","DOI":"10.1093\/ageing\/afu145"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:40:23Z","timestamp":1754912423000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":32,"alternative-id":["10.1136\/bcr-2014-207152"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207152","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,5,14]]}}}