{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:46Z","timestamp":1792525606191,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,2,9]]},"abstract":"<jats:p>A 61-year-old man presented with a 1-month history of breathlessness, chest pain and lethargy. He had been taking adalimumab for ankylosing spondylitis for 2\u2005years. Pleural and pericardial effusions were both found. A video-assisted thorascopic (VATS) pleural and lung biopsy were performed. The pleural pathology showed eosinophils, acute inflammatory cells and lymphoid aggregates. The patient was positive for antinuclear, antidouble-stranded and antihistone antibodies consistent with drug-induced lupus due to adalimumab. His serositis resolved on withdrawal of the drug. Drug-induced lupus can occur as a consequence of anti-TNF-\u03b1 agents from induction of autoimmunity in a predisposed host.<\/jats:p>","DOI":"10.1136\/bcr-2014-207323","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T04:41:31Z","timestamp":1425444091000},"page":"bcr2014207323","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Adalimumab-induced lupus serositis"],"prefix":"10.1136","volume":"2015","author":[{"given":"Dearbhla","family":"Kelly","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Cork University Hospital and School of Medicine, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oisin","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Cork University Hospital and School of Medicine, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Cork University Hospital and School of Medicine, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283642ad0"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151563"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21641"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.4","first-page":"688","article-title":"The natural history of ankylosing spondylitis. Does it burn out?","volume":"20","author":"Kennedy","year":"1993","journal-title":"J Rheumatol"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.5","first-page":"2288","article-title":"A single-dose, placebo-controlled study of the fully human anti-TNF antibody adalimumab (D2E7) in patients with rheumatoid arthritis","volume":"29","author":"den Broeder","year":"2002","journal-title":"J Rheumatol"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806023182209"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115353"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.9","doi-asserted-by":"publisher","DOI":"10.2165\/11588500-000000000-00000"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.10","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.019"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.11","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070000"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/rheumatology\/kep080","article-title":"Anti-TNF-induced lupus","volume":"48","author":"Williams","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.13","doi-asserted-by":"publisher","DOI":"10.1186\/ar1715"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.08.003"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0889-857X(21)00226-X","article-title":"Drug-induced lupus","volume":"20","author":"Yung","year":"1994","journal-title":"Rheum Dis Clin North Am"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408506102"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.17","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1431::AID-ANR3>3.0.CO;2-E"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.18","doi-asserted-by":"publisher","DOI":"10.1186\/ar1173"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.12.6821"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2003.01298.x"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.21","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181441a68"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1684\/ejd.2009.0668","article-title":"Adalimumab-induced lupus erythematosus","volume":"19","author":"Al-Niaimi","year":"2009","journal-title":"Eur J Dermatol"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00951.x"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.24","first-page":"559","article-title":"Adalimumab-induced lupus erythematosus in Crohn's disease patients previously treated with infliximab","volume":"57","author":"Ma\u00f1osa","year":"2008","journal-title":"Gut"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.25","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel227"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.26","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181837289"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.27","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0034"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.28","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00182308"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.29","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2383::AID-ANR2>3.0.CO;2-D"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.30","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050058"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.31","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.08.019"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.32","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2011.02612.x"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00522.x"},{"key":"2025082804552566000_2015.mar04_1.bcr2014207323.35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1177\/0961203314555171","article-title":"Characteristics of pleural effusions in systemic lupus erythematosus: differential diagnosis of lupus pleuritis","volume":"24","author":"Choi","year":"2014","journal-title":"Lupus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:55:34Z","timestamp":1756382134000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":35,"alternative-id":["10.1136\/bcr-2014-207323"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207323","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}