{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:40:03Z","timestamp":1756305603838,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,27]]},"abstract":"<jats:p>Kallmann's syndrome is a neuronal migration disorder characterised by anosmia\/hyposmia and hypogonadotropic hypogonadism. We present a case of a 21-year-old man who was unable to sense smell since birth and who displayed non-development of secondary sexual characteristics for the past 10\u2005years. Blood investigations showed low basal levels of serum follicle stimulating hormone (FSH), serum luteinising hormone (LH) and serum testosterone. After a gonadotropin releasing hormone challenge test there was a slight increase in serum FSH and serum LH, and after a human chorionic gonadotropin (HCG) challenge test the patient's serum testosterone level increased to 34 times that of his basal level. MRI of the brain showed absence of bilateral olfactory bulbs and sulcus with an apparently normal appearing pituitary gland, and bilateral loss of distinction between the gyrus rectus and medial orbital gyrus, thus confirming the diagnosis. The patient is on treatment with injection of HCG 2000\u2005IU deep intramuscular twice a week and is on follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2014-207386","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T02:54:35Z","timestamp":1418180075000},"page":"bcr2014207386","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Biochemical and MRI findings of Kallmann's syndrome"],"prefix":"10.1136","volume":"2014","author":[{"given":"Prafulla Kumar","family":"Dash","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, CMIIL-SCB Medical MRI Centre, Cuttack, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Harvey","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, CMIIL-SCB Medical MRI Centre, Cuttack, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"2025082707113927000_2014.dec09_1.bcr2014207386.1","first-page":"249","article-title":"\u201cGenetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory\u201d","volume":"22","author":"Mitchell","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"2025082707113927000_2014.dec09_1.bcr2014207386.2","unstructured":"Maestre de San Juan A . 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