{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:31:47Z","timestamp":1763641907101,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,4,3]]},"abstract":"<jats:p>Placental mesenchymal dysplasia (PMD) is a rare disorder of unknown aetiology characterised by placentomegaly, serpiginous surface blood vessels and large cystic villi. Although a mimic of molar pregnancies and other entities, it can be distinguished from them by its association with intrauterine growth restriction or death of a relatively normal fetus and its characteristic histopathology. We report the case of a 20-year-old primigravida who presented at 16\u2005weeks with heavy clotty vaginal bleeding and subsequent miscarriage. The placenta was grossly abnormal and resembled a partial molar pregnancy. PMD was confirmed by microscopic examination. Postmiscarriage, ultrasound revealed enlarged and multicystic ovaries similar to those seen in ovarian hyperstimulation syndrome (OHSS), which returned to normal a few weeks after miscarriage. This is the first report of PMD associated with OHSS, and we hypothesise that the most likely pathogenesis is ovarian stimulation from PMD-derived vascular endothelial growth factor.<\/jats:p>","DOI":"10.1136\/bcr-2014-207420","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T07:16:08Z","timestamp":1430205368000},"page":"bcr2014207420","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Placental mesenchymal dysplasia associated with spontaneous ovarian hyperstimulation syndrome"],"prefix":"10.1136","volume":"2015","author":[{"given":"Payam","family":"Davoudian","sequence":"first","affiliation":[{"name":"Department of Obs & Gynae, South West Acute Hospital, Enniskillen, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.1","unstructured":"Kaplan CG . Color atlas of gross placental pathology. New York: Springer, 2007."},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.2","doi-asserted-by":"publisher","DOI":"10.1309\/RV45HRD53YQ2YFTP"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80791-0"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5858\/2007-131-131-PMD","article-title":"Placental mesenchymal dysplasia","volume":"131","author":"Parveen","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.5","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.ajog.2011.08.019","article-title":"Placental mesenchymal dysplasia","volume":"205","author":"Woo","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2002.tb00897.x"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.7","first-page":"551","article-title":"Placental mesenchymal dysplasia complicated by hydrops fetalis and fetal death: a case report","volume":"16","author":"Akbarzadeh-Jahromi","year":"2013","journal-title":"Arch Iran Med"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12359"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.9","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.117164"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.10","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh124"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.8.2082"},{"key":"2025082801253465000_2015.apr28_1.bcr2014207420.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3319-0"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:25:46Z","timestamp":1756369546000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,28]]},"references-count":12,"alternative-id":["10.1136\/bcr-2014-207420"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207420","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,4,28]]}}}