{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:06:05Z","timestamp":1773252365791,"version":"3.50.1"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,12,6]]},"abstract":"<jats:sec><jats:title\/><jats:p>The pathophysiology of atypical haemolytic-uraemic syndrome (aHUS) occurring de novo after renal transplantation may include genetic mutations of regulators of complement activation, but they are still rarely determined. A 41-year-old female renal transplant recipient presented two very different episodes of thrombotic microangiopathy. The first episode was associated with antibody-mediated rejection and the second was an isolated, acute aHUS, successfully treated with eculizumab. The diagnosis included a genetic analysis and we found a synonymous variant in the Complement Factor H (CFH) gene, c2634C&gt;T (p.His878=) and low factor H (FH) activity during both events. In conclusion, the diagnosis of aHUS should be considered when TMA is associated with an AMR episode. In this setting, a silent polymorphism of factor H may be responsible for these rare cases of \u201cde novo\u201d aHUS after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bcr-2014-207630","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T12:50:16Z","timestamp":1419339016000},"page":"bcr2014207630","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["A \u2018silent\u2019, new polymorphism of factor H and apparent de novo atypical haemolytic uraemic syndrome after kidney transplantation"],"prefix":"10.1136","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-9335","authenticated-orcid":false,"given":"Emine N","family":"Broeders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Stordeur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Rorive","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajkd.2003.07.008"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02297.x"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.155"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.5","doi-asserted-by":"publisher","DOI":"10.1159\/000057850"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01686.x"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.7","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1681\/ASN.V1161132","article-title":"Thrombotic microangiopathy associated with parvovirus B19 infection after renal transplantation","volume":"11","author":"Murer","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.09.012"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.9","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.8.1075"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135308"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005036"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq495"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080868"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.14","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000115702.28859.A7"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038864"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.16","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.028"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02817.x"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0808527"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"2025042707112170000_2014.dec23_1.bcr2014207630.20","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.214"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:11:27Z","timestamp":1745763087000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":20,"alternative-id":["10.1136\/bcr-2014-207630"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207630","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]}}}