{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T19:02:01Z","timestamp":1766689321704,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,12,6]]},"abstract":"<jats:p>Breast carcinoma metastatic to the bladder is rare and accounts for approximately 3% of all secondary bladder neoplasms. We examine a case of breast cancer metastatic to the bladder with normal findings at cystoscopy. A 53-year-old woman with a history of breast carcinoma presented with a 6-month history of severe urgency and urgency incontinence. Treatment with multiple antimuscarinic therapies was unsuccessful. Vaginal examination demonstrated a non-mobile uterus with a suggestion of parametrial thickening. Urodynamic studies confirmed detrusor overactivity. CT showed a thickened bladder wall and cystoscopy revealed normal bladder mucosa with reduced bladder capacity. Bladder biopsies identified a poorly differentiated adenocarcinoma with strong oestrogen receptor staining. This was reported as a secondary deposit from a primary breast malignancy. The patient is currently under the care of the breast team and undergoing palliative chemotherapy.<\/jats:p>","DOI":"10.1136\/bcr-2014-207920","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T09:18:18Z","timestamp":1419239898000},"page":"bcr2014207920","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic breast cancer presenting as detrusor overactivity"],"prefix":"10.1136","volume":"2014","author":[{"given":"Aswini Aparna","family":"Balachandran","sequence":"first","affiliation":[{"name":"Department of Women's Health, Medway Maritime Hospital, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Duckett","sequence":"additional","affiliation":[{"name":"Medway Maritime Hospital, Kent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"2025082802595456000_2014.dec22_1.bcr2014207920.1","first-page":"243","article-title":"Urinary complications from breast cancer metastasis: a case report and review of the literature","volume":"31","author":"Vulcano","year":"2010","journal-title":"G Chir"},{"key":"2025082802595456000_2014.dec22_1.bcr2014207920.2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0090-4295(01)01489-3","article-title":"Metastatic breast cancer to the bladder: a diagnostic challenge and review of the literature","volume":"59","author":"Feldman","year":"2002","journal-title":"Urology"},{"key":"2025082802595456000_2014.dec22_1.bcr2014207920.3","doi-asserted-by":"crossref","unstructured":"Abrams P , Kelleher C , Staskin D , et al . Combination treatment with mirabegron and solifenacin in patients with overactive bladder: efficacy and safety results from a randomized, double-blind, dose-ranging, Phase 2 study (Symphony). Eur Urol. 2014:pii: S0302-2838(14)00131-6. http:\/\/dx.doi.org\/10.1016\/j.eururo.2014.02.012","DOI":"10.1016\/j.eururo.2014.02.012"},{"key":"2025082802595456000_2014.dec22_1.bcr2014207920.4","doi-asserted-by":"crossref","unstructured":"Balachandran A , Curtiss N , Basu M , et al . Third-line treatment for overactive bladder: should mirabegron be tried before intravesical botulinum toxin A therapy? Int Urogynecol J 2014. Published Online First. 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