{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:40:03Z","timestamp":1745746803253,"version":"3.40.4"},"reference-count":40,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,28]]},"abstract":"<jats:p>We describe a rare case of light chain immunoglobulin amyloid (AL) accumulation in the central and lower pole renal calyces. Our patient, a woman aged 60, presented with several episodes of gross haematuria. Radiological imaging detected a filling defect in the left renal pelvis. Rigid ureteroscopy showed a corresponding mucosal abnormality resembling transitional cell carcinoma. A definitive preoperative tissue diagnosis could not be reached. Laparoscopic-assisted left nephroureterectomy was indicated. Histopathological examination excluded malignancy, revealing congophilic deposits of submucosal amyloid. A constellation of findings confirmed localised or primary amyloidosis with an AL immunophenotype but no evidence of clonal B-cell disease in the amyloid-associated lymphoplasmacytic cell infiltrate. Investigation for systemic plasma cell dyscrasia and echocardiography and scintigraphy for visceral amyloid deposits were negative for systemic disease. At a follow-up period of 30\u2005months, there is no recurrence. However, our patient was diagnosed with breast cancer 21\u2005months ago.<\/jats:p>","DOI":"10.1136\/bcr-2014-207955","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T18:03:55Z","timestamp":1421431435000},"page":"bcr2014207955","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Amyloidosis of the renal pelvis: a harbinger of mammary carcinoma?"],"prefix":"10.1136","volume":"2015","author":[{"given":"Thomas","family":"Grigor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Munro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.1","doi-asserted-by":"publisher","DOI":"10.1021\/ar050069h"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20381"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.3","doi-asserted-by":"publisher","DOI":"10.1089\/end.2009.0383"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5542.736"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.5","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(79)90092-X"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1464-410X.1984.tb05369.x","article-title":"Localised primary amyloidosis of the renal pelvis","volume":"56","author":"Fox","year":"1984","journal-title":"Br J Urol"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.7","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(80)90382-9"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1994.tb07466.x"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.9","first-page":"423","article-title":"A case of amyloidosis of the renal pelvis","volume":"49","author":"Iida","year":"2003","journal-title":"Hinyokika Kiyo"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.10","doi-asserted-by":"publisher","DOI":"10.1080\/13506120802676740"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197105272842107"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-5347(17)68179-5","article-title":"Primary amyloidosis of the renal pelvis and ureter: report of case","volume":"68","author":"Gilbert","year":"1952","journal-title":"J Urol"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.11.029"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.14","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31821cbdab"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.15","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(86)90420-6"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.16","doi-asserted-by":"publisher","DOI":"10.1148\/rg.327115157"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.17","doi-asserted-by":"publisher","DOI":"10.1016\/S1001-9294(11)60049-7"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(83)80008-9"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.19","first-page":"406","article-title":"Pyelo-ureteric amyloidosis","volume":"14","author":"Savareux","year":"2004","journal-title":"Prog Urol"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.20","first-page":"530","article-title":"Primary localized AA type amyloidosis of the renal pelvis, ureter and bladder","volume":"28","author":"Shi","year":"2012","journal-title":"Pak J Med Sci"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.21","first-page":"699","article-title":"Primary localized amyloidosis of the renal pelvis coexisting with transitional cell carcinoma: a case report","volume":"38","author":"Shiramizu","year":"1992","journal-title":"Hinyokika Kiyo"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.22","doi-asserted-by":"publisher","DOI":"10.1159\/000282135"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.23","first-page":"1494","article-title":"A case of a primary localized amyloidosis (amyloid tumor) of the renal pelvis and ureter","volume":"33","author":"Suzuki","year":"1987","journal-title":"Gan No Rinsho"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.24","first-page":"29","article-title":"Primary amyloidosis of the renal pelvis: a case report and review of literature","volume":"72","author":"Ullmann","year":"1973","journal-title":"Mich Med"},{"key":"2025042702212740000_2015.jan16_2.bcr2014207955.25","first-page":"665","article-title":"Amyloidosis (AL). 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