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After this occurred twice more, finally a right common iliac and femoral vein stent was placed to prevent clot reaccumulation and vein stenosis. Hypercoagability testing revealed activated protein C resistance and genetic testing confirmed homozygous Factor V Leiden (FVL). Family history was significant for maternal lower extremity DVT at age 21 and possible DVT in the patient's maternal grandmother.<\/jats:p>","DOI":"10.1136\/bcr-2014-207959","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T11:47:38Z","timestamp":1427975258000},"page":"bcr2014207959","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Phlegmasia cerulea dolens in a teenage boy found to have Factor V Leiden"],"prefix":"10.1136","volume":"2015","author":[{"given":"Emily","family":"Junck","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachita","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,4,2]]},"reference":[{"key":"2025082803462773000_2015.apr02_1.bcr2014207959.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00158.x"},{"key":"2025082803462773000_2015.apr02_1.bcr2014207959.2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118192"},{"key":"2025082803462773000_2015.apr02_1.bcr2014207959.3","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood.V83.5.1251.1251","article-title":"Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE","volume":"83","author":"Andrew","year":"1994","journal-title":"Blood"},{"key":"2025082803462773000_2015.apr02_1.bcr2014207959.4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1160\/TH04-04-0207","article-title":"Systemic thromboembolism in children: data from the 1-800-NO-CLOTS Consultation Service","volume":"92","author":"Kuhle","year":"2004","journal-title":"Thromb Haemost"},{"key":"2025082803462773000_2015.apr02_1.bcr2014207959.5","unstructured":"U.S. National Library of Medicine, National Institutes of Health. 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