{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:45:49Z","timestamp":1756385149341,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2014,11,28]]},"abstract":"<jats:p>There is no established therapeutic option for corticosteroid (CS) refractory drug-induced interstitial lung disease (DILD). We report a case of CS refractory severe DILD successfully treated with recombinant human soluble thrombomodulin (rhTM). A 64-year-old Japanese man was admitted with symptoms of fever, dry cough and dyspnoea. A chest radiograph showed bilateral infiltrations. DILD from Nijutsutou, a Chinese medicine, was suspected based on a history of similar interstitial lung disease after its administration 4\u2005years prior and a positive drug-induced lymphocyte stimulation test. Nijutsutou was promptly discontinued and high doses of CS administered, but the patient's bilateral infiltrations remained unimproved. Since coagulation tests also indicated a rapid aggravation of coagulopathy, rhTM was added to the CS therapy. The patient's lung infiltration ameliorated and plasma levels of D-dimer and high morbidity group box 1 (HMGB1) decreased. rhTM may be an alternative agent for CS refractory DILD. Further study is necessary to confirm this.<\/jats:p>","DOI":"10.1136\/bcr-2014-207996","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T05:53:20Z","timestamp":1418795600000},"page":"bcr2014207996","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Severe drug-induced interstitial lung disease successfully treated with corticosteroid plus recombinant human soluble thrombomodulin"],"prefix":"10.1136","volume":"2014","author":[{"given":"Satoshi","family":"Marumo","sequence":"first","affiliation":[{"name":"Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Shirata","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Sakuramoto","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonari","family":"Fukui","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b25.x"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.07.015"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02267.x"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2014.04.008"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2013.09.001"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.6","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2001.0792"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1475"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.10","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-19-34"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.11","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12106"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04319.x"},{"key":"2025082805072157000_2014.dec17_1.bcr2014207996.13","doi-asserted-by":"publisher","DOI":"10.2174\/092986710791233706"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-207996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:07:30Z","timestamp":1756382850000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-207996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":13,"alternative-id":["10.1136\/bcr-2014-207996"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-207996","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2014,12,17]]}}}