{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:56:28Z","timestamp":1785412588717,"version":"3.56.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,3,25]]},"abstract":"<jats:p>Hyponatraemia is the most commonly encountered electrolyte abnormality in clinical practice. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) accounts for nearly 60% of all hyponatraemias. Selective serotonin reuptake inhibitors (SSRIs) are well known to have side effects of SIADH. There have been few reported cases of serotonin norepinephrine reuptake inhibitors (SNRIs) causing SIADH-induced hyponatraemia. Duloxetine is one type of SNRI used to treat several conditions, including depression and diabetic neuropathy. We present a case of a 76-year-old woman with a history of fibromyalgia who had recently been prescribed duloxetine for her condition. On admission to the hospital, her sodium decreased to a low of 118\u2005mmol\/L. Evaluation for other causes of hyponatraemia yielded negative results. Duloxetine was discontinued and after 3\u2005days the patient's sodium increased to 130\u2005mmol\/L. The purpose of this case report is to highlight the importance of having suspicion for rare but real side effects of medications such as duloxetine.<\/jats:p>","DOI":"10.1136\/bcr-2014-208037","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T06:00:33Z","timestamp":1429855233000},"page":"bcr2014208037","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Syndrome of inappropriate antidiuretic hormone secretion: a story of duloxetine-induced hyponatraemia"],"prefix":"10.1136","volume":"2015","author":[{"given":"Adae Opoku","family":"Amoako","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Brown","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Hershey, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.08.055"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1532-5415.1996.tb06410.x","article-title":"Apparent idiopathic hyponatremia in an ambulatory geriatric population","volume":"44","author":"Miller","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-002-0438-5"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.4","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfp155"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.5","doi-asserted-by":"publisher","DOI":"10.5234\/cnpt.3.33"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5694\/j.1326-5377.2003.tb05635.x","article-title":"Mirtazapine-induced hyponatraemia","volume":"179","author":"Roxanas","year":"2003","journal-title":"Med J Aust"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.7","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2009.765"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.8","first-page":"3750","article-title":"A case of severe hyponatremia induced by duloxetine and ziprasidone","volume":"125","author":"Li","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.9","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31802e688a"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.10","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2012.9.1.83"},{"key":"2025082706574619000_2015.apr23_1.bcr2014208037.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.09.001"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-208037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T13:57:53Z","timestamp":1756303073000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-208037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,24]]},"references-count":11,"alternative-id":["10.1136\/bcr-2014-208037"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-208037","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,24]]}}}