{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:11:51Z","timestamp":1784675511218,"version":"3.55.0"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,2,3]]},"abstract":"<jats:p>Rituximab is used for treatment of multiple haematological cancers. Caution for use is advised in patients with significant cardiorespiratory disease due to known cases of exacerbations of angina and arrhythmias. However, its cardiotoxicity profile is not as well recognised as other monoclonal antibodies such as transtuzumab. We report a case of a 66-year-old man who developed Takotsubo's cardiomyopathy (TC) after an elective infusion of rituximab. This case is exceptional in that rituximab has not been linked to TC, and the vast majority of chemotherapy-linked and immunotherapy-linked TC reactions have occurred during initial infusions. We also discuss the different mechanisms which link TC to immunotherapy and chemotherapy, and propose that there may be a potential for risk-stratifying recipients of this frequently used immunotherapy prior to administering treatment.<\/jats:p>","DOI":"10.1136\/bcr-2014-208203","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T06:17:18Z","timestamp":1425277038000},"page":"bcr2014208203","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Rituximab-induced Takotsubo syndrome: more cardiotoxic than it appears?"],"prefix":"10.1136","volume":"2015","author":[{"given":"Kien Hoe","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dearden","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Gruber","sequence":"additional","affiliation":[{"name":"Royal Marsden Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.5278"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.669341"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01316-X"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl032"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.5","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120403"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133187.74800.B9"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.7","first-page":"E338","article-title":"Chemotherapy-induced Takotsubo cardiomyopathy","volume":"20","author":"Kim","year":"2008","journal-title":"J Invasive Cardiol"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1200\/JCO.2000.18.2.317","article-title":"European Phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle cell lymphoma and previously treated mantle cell lymphoma, immunocytoma, and small B lymphocytic lymphoma","volume":"18","author":"Foran","year":"2000","journal-title":"J Clin Oncol"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.9","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-008-9062-2"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.10","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/ajhp\/60.16.1631","article-title":"Monoclonal antibodies in the treatment of cancer, part 2","volume":"60","author":"Cercosimo","year":"2003","journal-title":"Am J Health Syst Pharm"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.11","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.87003"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20303"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006341717398"},{"key":"2025082802545490000_2015.mar02_1.bcr2014208203.14","unstructured":"Rituxan official FDA information, side effects and uses. 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