{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:07:38Z","timestamp":1756382858755,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,9,23]]},"abstract":"A previously healthy 29-year-old man was admitted to our hospital, with a 4-day history of fever (>39\u00b0C), rigours, diaphoresis, fatigue and retro-orbital headache. On examination, he was febrile (37.8\u00b0C) and tachycardic (110\u2005bpm). Laboratory work up revealed bicytopenia (white cell count 1.37\u00d7109<\/jats:sup>\/L, platelets 60\u00d7109<\/jats:sup>\/L) and an increase in C reactive protein (9\u2005mg\/dL). The ECG showed ST segment elevation in V1, V2 and V3 leads. The patient was admitted and investigation was initiated revealing prolonged fever (>7\u2005days), pancytopenia, hepatosplenomegaly, hyperferritinemia, hypertriglyceridemia, hypofibrinogenemia, elevated soluble CD25 and hemophagocytosis in bone marrow. Therefore, the patient presented 7 of the 8 diagnostic criteria of hemophagocytic syndrome. Laboratorial investigation for infectious causes was negative, except for IgA and IgG Chlamydophila pneumoniae<\/jats:italic>. ECG re-evaluation on the day of discharge showed no ST segment elevation and no other abnormalities. Genetic testing for known mutations associated with hemophagocytic syndrome and Brugada syndrome did not show any mutations in these genes.<\/jats:p>","DOI":"10.1136\/bcr-2014-208863","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T07:37:15Z","timestamp":1444376235000},"page":"bcr2014208863","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Fever-triggered Brugada syndrome in an adult patient presenting with hemophagocytic syndrome induced by Chlamydophila pneumoniae<\/i>"],"prefix":"10.1136","volume":"2015","author":[{"given":"Miguel","family":"Bigotte Vieira","sequence":"first","affiliation":[{"name":"Nephrology Department, Hospital Santa Maria\u2014Centro Hospitalar Lisboa Norte, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Gaibino","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Santa Maria\u2014Centro Hospitalar Lisboa Norte, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Pignatelli","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital Santa Maria\u2014Centro Hospitalar Lisboa Norte, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabela","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Santa Maria\u2014Centro Hospitalar Lisboa Norte, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"2025082722383942000_2015.oct09_2.bcr2014208863.1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2025082722383942000_2015.oct09_2.bcr2014208863.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"2025082722383942000_2015.oct09_2.bcr2014208863.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-0894-9"},{"key":"2025082722383942000_2015.oct09_2.bcr2014208863.4","first-page":"555","article-title":"Q fever\u2014a review","volume":"31","author":"Marrie","year":"1990","journal-title":"Can Vet J"},{"key":"2025082722383942000_2015.oct09_2.bcr2014208863.5","unstructured":"Anderson A , Bijlmer H , Fournier PE , et al . 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