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It is characterised by delayed separation of the umbilical cord, recurrent bacterial and fungal infections, defective wound healing, blood neutrophilia and a high mortality rate at an early age. We report the second fatal case of an infant with LAD-I diagnosed in Chile, with developmental delay associated with a congenital cytomegalovirus infection. CD18\/CD11 expression was normal. Genetic analysis of CD18 revealed a homozygous mutation in ITGB2, viz.c.1835G&gt;T; p.C612F, and led us to suspect a biological parent other than the legal father and, therefore, an unwanted social situation.<\/jats:p>","DOI":"10.1136\/bcr-2014-208973","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T11:30:58Z","timestamp":1428579058000},"page":"bcr2014208973","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Leucocyte adhesion deficiency type 1 with developmental delay secondary to CMV infection and filiation questions"],"prefix":"10.1136","volume":"2015","author":[{"given":"Alexis","family":"Strickler","sequence":"first","affiliation":[{"name":"Department of Paediatrics, San Sebastian University, Puerto Montt Hospital Chile, Puerto Montt, 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