{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:20:02Z","timestamp":1762352402753,"version":"3.40.4"},"reference-count":26,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,2,19]]},"abstract":"<jats:p>We report a case of life-threatening myxoedema presenting with hypothermia, hypotension, bradycardia, pericardial effusion and deep coma. The condition was complicated by prolonged status epilepticus. The optimal treatment strategy has been debated over the years and the literature is briefly reviewed. Treatment with<jats:sc>l<\/jats:sc>-thyroxine (LT4) monotherapy without initial loading dose and with no<jats:sc>l<\/jats:sc>-triiodothyronine (LT3) treatment was successful with full recovery after hospitalisation for more than a month. Myxoedema coma is a rare, reversible condition with a high mortality and should be considered as a differential diagnosis in medical emergencies.<\/jats:p>","DOI":"10.1136\/bcr-2014-209071","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T08:46:26Z","timestamp":1427273186000},"page":"bcr2014209071","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Complete recovery after severe myxoedema coma complicated by status epilepticus"],"prefix":"10.1136","volume":"2015","author":[{"given":"Jesper","family":"Fj\u00f8lner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2006.09.003"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1999.9.1167"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.3","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1800347"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.4","doi-asserted-by":"publisher","DOI":"10.1186\/cc6211"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.5","doi-asserted-by":"publisher","DOI":"10.1186\/cc6218"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.6","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197212000-00001"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/0885066607301361","article-title":"Myxedema coma","volume":"22","author":"Kwaku","year":"2013","journal-title":"J Intensive Care Med"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196203222661207"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.9","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v05n0603"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.8.3864"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.11","first-page":"202","article-title":"Status epilepticus caused by a myxoedema coma","volume":"64","author":"Jansen","year":"2006","journal-title":"Neth J Med"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.12","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.53.615.46"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.13","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200603000-00008"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.14","doi-asserted-by":"publisher","DOI":"10.1159\/000313464"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.15","first-page":"1849","article-title":"[Cardiovascular manifestations of hypothyroidism]","volume":"26","author":"Nyrop","year":"1991","journal-title":"Ugeskr L\u00e6ger"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.16","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90167-N"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.17","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-277"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.18","doi-asserted-by":"crossref","unstructured":"Dyson A , Wood M . Treatment of myxoedema coma. Lancet 1956;:768\u20139.","DOI":"10.1016\/S0140-6736(56)90969-2"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022933918182"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.20","doi-asserted-by":"crossref","first-page":"493462","DOI":"10.4061\/2011\/493462","article-title":"Myxedema coma: a new look into an old crisis","volume":"2011","author":"Mathew","year":"2011","journal-title":"J Thyroid Res"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.21","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198302000-00009"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.22","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1080065"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708403"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0025-7125(16)30091-8","article-title":"Myxedema coma. Pathophysiology, therapy, and factors affecting prognosis","volume":"79","author":"Jordan","year":"1995","journal-title":"Med Clin North Am"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2012.01.015"},{"key":"2025042705463292000_2015.mar24_2.bcr2014209071.26","first-page":"2485","article-title":"Myxoedema coma diagnosis and treatment","volume":"62","author":"Wall","year":"2000","journal-title":"Am Fam Physician"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2014-209071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:46:47Z","timestamp":1745758007000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2014-209071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":26,"alternative-id":["10.1136\/bcr-2014-209071"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2014-209071","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}