{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:09:31Z","timestamp":1760044171310,"version":"3.40.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,9,2]]},"abstract":"<jats:p><jats:italic>Clostridium septicum<\/jats:italic>(CS) is a rare organism that accounts for only 1.3% of all clostridial infections. However, its detection is of great clinical significance, as over 80% of cases are associated with malignancy, often occult; the most common primary sites are the ascending colon and caecum, and the most common cause is haematological malignancy. We report a case of a 79-year-old woman, admitted with shortness of breath and left-sided chest pain, who, following subsequent investigations, was found to have CS aortitis. She was further evaluated with CT of the abdomen followed by colonoscopy and biopsy, which revealed adenocarcinoma of the caecum with liver metastasis. The CS aortitis has a reported mortality of 100% if left untreated. Therefore prompt intervention and surgical debridement is recommended. Despite these recommendations, our patient had some delays in her treatment and did not undergo surgical debridement due to frailty. We believe that it is highly unusual for a patient such as ours to have survived both the aortitis and the colonic malignancy, after undergoing endovascular radiological intervention and antibiotic therapy, without surgical debridement.<\/jats:p>","DOI":"10.1136\/bcr-2015-209437","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T12:02:40Z","timestamp":1442318560000},"page":"bcr2015209437","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["An atypical presentation of colonic malignancy:<i>Clostridium septicum<\/i>aortitis"],"prefix":"10.1136","volume":"2015","author":[{"given":"Arshiya","family":"Tabasum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bleehen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198901000-00002"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-9-1-63"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.3","first-page":"473","article-title":"Localization of the vegetative form of Clostridium tetani ill mouse tumors following intravenous spore administration","volume":"15","author":"Malmgren","year":"1955","journal-title":"Cancer Res"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.4","first-page":"234","article-title":"Effect of non pathogenic clostridial spores in normal and pathological tissues","volume":"24","author":"Thiele","year":"1964","journal-title":"Cancer Res"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.11.058"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2045::AID-CNCR2820571028>3.0.CO;2-O"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.80.4.309"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.8","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/jb.76.5.538-545.1958","article-title":"Complexity of toxins from Clostridium septicum and Clostridium chauvoei","volume":"76","author":"Moussa","year":"1958","journal-title":"J Pathol Bacteriol"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04774.x"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160160021004"},{"key":"2025042707074766000_2015.sep15_1.bcr2015209437.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)80055-3"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-209437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:07:56Z","timestamp":1745762876000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-209437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":11,"alternative-id":["10.1136\/bcr-2015-209437"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-209437","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}