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CT scan of the head was non-revealing and laboratory tests including complete blood count, serum comprehensive metabolic panel and coagulation profile were within normal limits. Aseptic meningitis in the setting of cetuximab therapy has been reported on 6 previous occasions. Consistent with these prior reports, it is interesting to note that this case also occurred after administration of the initial higher loading dose of Cetuximab. This is of interest as Cetuximab is more frequently being dosed at 500\u2005mg\/m<jats:sup>2<\/jats:sup>(higher dose) every 2\u2005weeks in colorectal cancer.<\/jats:p>","DOI":"10.1136\/bcr-2015-209622","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T14:50:08Z","timestamp":1431442208000},"page":"bcr2015209622","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["More than a headache: a case of cetuximab-induced aseptic meningitis"],"prefix":"10.1136","volume":"2015","author":[{"given":"Devika","family":"Prasanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Elrafei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Shum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Strakhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"2025042706162761000_2015.may12_1.bcr2015209622.1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767170-00008"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155212447973"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.3","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181d408bc"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.4","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp382"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.5","first-page":"3","article-title":"Aseptic meningitis as a rare but serious side effect of cetuximab therapy","volume":"4","author":"Vulsteke","year":"2010","journal-title":"Belg J Med Oncol"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2008.07.002"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.11.015"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.8","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90154-1"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1200\/JCO.2000.18.11.2349","article-title":"Trastuzumab in CSF","volume":"18","author":"Pestalozzi","year":"2000","journal-title":"J Clin Oncol"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000236313.50833.ee"},{"key":"2025042706162761000_2015.may12_1.bcr2015209622.11","unstructured":"Weiner HL , Curing MS . 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