{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:38Z","timestamp":1787017058899,"version":"build-2736575974"},"reference-count":20,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,6,26]]},"abstract":"<jats:p>Epidermolysis bullosa acquisita is a rare, acquired, autoimmune subepidermal blistering disease of the skin, characterised by blisters and erosions, especially in trauma-prone sites and extensor skin surface, scarring with formation of milia, skin fragility and nail dystrophy. Epidermolysis bullosa acquisita is extremely rare in childhood and it has been reported to be frequently associated with Crohn's disease. Furthermore, autoantibodies against type VII collagen have been found in a large number of patients with Crohn's disease without epidermolysis bullosa acquisita. We report a case of a 17-year-old boy affected by Crohn's disease who presented with milia on infiltrated erythematous plaques over the back of the hands. The diagnosis of epidermolysis bullosa acquisita was confirmed by histopathology, direct and indirect immunofluorescence analysis and ELISA.<\/jats:p>","DOI":"10.1136\/bcr-2015-210210","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T04:24:27Z","timestamp":1436502267000},"page":"bcr2015210210","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Epidermolysis bullosa acquisita in a 17-year-old boy with Crohn's disease"],"prefix":"10.1136","volume":"2015","author":[{"given":"Irene","family":"Russo","sequence":"first","affiliation":[{"name":"Unit of Dermatology, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ferrazzi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Alaibac","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,7,10]]},"reference":[{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphys.2012.00013","article-title":"Skin manifestations of inflammatory bowel disease","volume":"3","author":"Huang","year":"2012","journal-title":"Front Physiol"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.2","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.3","first-page":"158","article-title":"Cutaneous manifestations of inflammatory bowel disease","volume":"1","author":"Georgiou","year":"2006","journal-title":"Hosp Chron"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.4","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.031633"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23702.x"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.03.011"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000130003001"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04919.x"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890450070008"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01509.x"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.11","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12114"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01772.x"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.13","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1111\/j.1582-4934.2009.00959.x","article-title":"Autoimmunity against type VII collagen in inflammatory bowel disease","volume":"14","author":"Hundorfean","year":"2009","journal-title":"J Cell Mol Med"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00081.x"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.15","doi-asserted-by":"publisher","DOI":"10.2174\/15665240113136660079"},{"key":"2025082800095599000_2015.jul10_1.bcr2015210210.16","doi-asserted-by":"crossref","unstructured":"Kirtschig G , Murrel D , Wojnarowska F , et al . Interventions for mucous membrane pemphigoid and epidermolysis bullosa acquisita. 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