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Cryptococcal infection may occur in an immunocompetent patient, but the pathogenic strain is usually<jats:italic>Cryptococcus gattii<\/jats:italic>, and not<jats:italic>C. neoformans.<\/jats:italic>However, disseminated disease, especially cerebral involvement in the form of primary intraventricular haemorrhage, is exceedingly rare. We report a case of disseminated cryptococcosis with cutaneous, cerebral and bone marrow involvement in an HIV-negative, apparently immunocompetent patient. Although the patient did not have the usual immunocompromising diseases, there were clinical signs possibly indicating a weakened immune system. This report highlights the need for awareness of disseminated cryptococcosis among patients with no apparent immunocompromising conditions.<\/jats:p>","DOI":"10.1136\/bcr-2015-210250","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T12:17:47Z","timestamp":1445602667000},"page":"bcr2015210250","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Disseminated cryptococcosis in an apparently immunocompetent patient presenting with primary intraventricular haemorrhage"],"prefix":"10.1136","volume":"2015","author":[{"given":"Partha","family":"Pal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayantan","family":"Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisir Kumar","family":"Patra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.1","DOI":"10.1016\/j.ijid.2004.12.004"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.2","DOI":"10.1111\/j.1439-0507.2005.01136.x"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.3","DOI":"10.1111\/j.1567-1364.2006.00088.x"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.4","DOI":"10.1111\/j.1469-0691.2009.02919.x"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.5","DOI":"10.4103\/0255-0857.37349"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.6","DOI":"10.1016\/j.idc.2006.07.001"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.7","DOI":"10.4103\/0028-3886.35682"},{"key":"2025042707282993000_2015.oct22_1.bcr2015210250.8","first-page":"858","article-title":"Mycotic aneurysm and cerebral infarction resulting from fungal sinusitis: imaging and pathologic correlation","volume":"22","author":"Hurst","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.9","DOI":"10.1590\/S0036-46652002000400008"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.10","DOI":"10.1007\/s10096-007-0430-1"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.11","DOI":"10.1097\/01.mph.0000130218.49155.09"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.12","DOI":"10.1001\/archinte.1977.03630170084019"},{"key":"2025042707282993000_2015.oct22_1.bcr2015210250.13","first-page":"652351","article-title":"Disseminated cryptococcosis in an immunocompetent patient: a case report","volume":"2012","author":"Suchitha","year":"2012","journal-title":"Case Rep Pathol"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.14","DOI":"10.1056\/NEJMicm1309435"},{"key":"2025042707282993000_2015.oct22_1.bcr2015210250.15","first-page":"38","article-title":"Disseminated cryptococcosis with cutaneous manifestations","volume":"20","author":"Wang","year":"2002","journal-title":"Dermatol Sinica"},{"doi-asserted-by":"publisher","key":"2025042707282993000_2015.oct22_1.bcr2015210250.16","DOI":"10.1086\/649858"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-210250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:28:40Z","timestamp":1745764120000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-210250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,22]]},"references-count":16,"alternative-id":["10.1136\/bcr-2015-210250"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-210250","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,10,22]]}}}