{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:07:46Z","timestamp":1759342066003,"version":"3.40.4"},"reference-count":26,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,1,16]]},"abstract":"<jats:p>We present a case of a young adult with both Cornelia de Lange syndrome and Ehlers-Danlos syndrome. The patient showed non-verbal autism, intellectual disability and severe\/intractable self-harming behaviours that led to a life-threatening complication (ie, septicaemia). A significant reduction in the self-harming behaviours was attained in a multidisciplinary neurobehavioural inpatient unit after addressing all causes of somatic pains, managing pain using level II and III analgesics, stabilising the patient's mood, limiting the iatrogenic effects of multiple prescriptions and offering a specific psychoeducational approach.<\/jats:p>","DOI":"10.1136\/bcr-2015-210925","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T11:27:32Z","timestamp":1454326052000},"page":"bcr2015210925","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Cornelia de Lange and Ehlers-Danlos: comorbidity of two rare syndromes"],"prefix":"10.1136","volume":"2016","author":[{"given":"Cora","family":"Cravero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Guinchat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Barete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e8le","family":"Consoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-118.4.262"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.2","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/ajmg.a.34014","article-title":"Investigation of autistic features among individuals with mild to moderate Cornelia de Lange syndrome","volume":"158A","author":"Nakanishi","year":"2012","journal-title":"Am J Med Genet A"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.3","first-page":"241","article-title":"A study of the dermatoglyphs in the de Lange syndrome","volume":"10","author":"Smith","year":"1966","journal-title":"J Ment Defic Res"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.4","doi-asserted-by":"publisher","DOI":"10.1086\/424698"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201737"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.douler.2014.09.003","article-title":"Les multiples douleurs du syndrome d'Ehlers-Danlos. Description et proposition d'un protocole th\u00e9rapeutique","volume":"15","author":"Hamonet","year":"2014","journal-title":"Douleurs Evaluation\u2014Diagnostic\u2014Traitement."},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.12.020"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.9","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ff67ba"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.10","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20107"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.11","unstructured":"Macintyre PE , Scott DA , Schug SA , et al . Acute pain management: scientific evidence. 3rd edn. Melbourne, Australia: Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine. 2010:491."},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0900H"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eurpsy.2010.03.003","article-title":"Second-generation antipsychotics and constipation: a review of the literature","volume":"26","author":"De Hert","year":"2011","journal-title":"Eur Psychiatry"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.14","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/pme.12937","article-title":"Consensus recommendations on initiating prescription therapies for opioid-induced constipation","volume":"16","author":"Argoff","year":"2015","journal-title":"Pain Med"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.31887\/DCNS.2012.14.3\/cdoyle","article-title":"Pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders across the lifespan","volume":"14","author":"Doyle","year":"2012","journal-title":"Dialogues Clin Neurosci"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.16","doi-asserted-by":"publisher","DOI":"10.1901\/jaba.2002.35-69"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2013.07.003"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-0100-1"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.19","first-page":"100","article-title":"Risk factors of acute behavioral regression in psychiatrically hospitalized adolescents with autism","volume":"19","author":"P\u00e9risse","year":"2010","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.20","first-page":"265","article-title":"Psychopharmacology and applied behavioral analysis: tandem treatment of severe problem behaviors in intellectual disability and a case series","volume":"43","author":"Wachtel","year":"2006","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.21","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e318213f56c"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.22","doi-asserted-by":"publisher","DOI":"10.1177\/1362361301005003004"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ajmg.c.30137","article-title":"Natural history of aging in Cornelia de Lange syndrome","volume":"145C","author":"Kline","year":"2007","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.24","doi-asserted-by":"publisher","DOI":"10.1177\/1362361308091650"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.25","doi-asserted-by":"publisher","DOI":"10.1177\/1362361307070987"},{"key":"2025042702370767000_2016.jan31_1.bcr2015210925.26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-1130.2007.00109.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-210925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:37:15Z","timestamp":1745746635000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-210925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,1]]},"references-count":26,"alternative-id":["10.1136\/bcr-2015-210925"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-210925","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,2,1]]}}}