{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:56:09Z","timestamp":1759776969969,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,9,1]]},"abstract":"<jats:p>Gingival \ufb01bromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary\/idiopathic gingival \ufb01bromatosis), and\/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.<\/jats:p>","DOI":"10.1136\/bcr-2015-211071","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T04:07:41Z","timestamp":1442808461000},"page":"bcr2015211071","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Generalised fibrotic gingival enlargement in a psoriatic patient: an association or a coincidence?"],"prefix":"10.1136","volume":"2015","author":[{"given":"Smitha Rani","family":"Thada","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindranath","family":"Vineetha","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthilatha M","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal University, Manipal, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,9,21]]},"reference":[{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.59566\/IJBS.2009.5198","article-title":"Idiopathic gingival hyperplasia","volume":"5","author":"Ferhat","year":"2009","journal-title":"Int J Biomed Sci"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.2","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.5897\/AJB10.020","article-title":"Psoriasis: a review of the role of serotonergic system","volume":"9","author":"Ronpirin","year":"2010","journal-title":"Afr J Biotechnol"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.3","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.4","first-page":"14","article-title":"Oral manifestations of psoriasis. 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The gingival fibromatoses, underlying mechanisms of epilepsy. Kaneez FS , ed. InTech, 2011. ISBN: 978-953-307-765-9. http:\/\/www.intechopen.com\/books\/underlying-mechanisms-of-epilepsy\/the-gingival-fibromatoses"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.10","unstructured":"Mostafa I , Maha A , Mennat M , et al . Genetic disorders associated with gingival enlargement, gingival diseases\u2014their aetiology, prevention and treatment. Panagakos F , ed. InTech, 2011. ISBN: 978-953-307-376-7. http:\/\/www.intechopen.com\/books\/gingival-diseases-their-aetiology-prevention-and-treatment\/geneticdisorders-associated-with-gingival-enlargement"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1626.2011.00054.x"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.12","first-page":"240","article-title":"Unusual clinical presentation of generalised gingival enlargement\u2014a report of 3 cases","volume":"4","author":"Smitha Rani","year":"2012","journal-title":"Int J Collaborative Res Intern Med Public Health"},{"key":"2025082723270593000_2015.sep21_1.bcr2015211071.13","doi-asserted-by":"crossref","unstructured":"Ileana MB , Cristina M , Anca BI , et al . Epithelial-mesenchymal transition\u2014a possible pathogenic pathway of fibrotic gingival overgrowth. In: Open access book of \u201cemerging trends in oral health sciences and dentistry\u201d. Virdi MS , ed. 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