{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:08:37Z","timestamp":1764828517929,"version":"3.40.4"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,7,20]]},"abstract":"<jats:p>Pheochromocytomas are rare tumours originating in chromaffin cells, representing 0.1\u20131% of all secondary hypertension (HT) cases. The majority are benign and unilateral, characterised by the production of catecholamines and other neuropeptides. Mainly located in the adrenal gland, they are more frequent between the 3rd and 5th decades of life; however, 10\u201325% can be associated with genetic familial syndromes (multiple endocrine neoplasia type 2 (MEN 2), type 1 neurofibromatosis and Von-Hippel-Landau disease in younger ages. The authors present a rare case of secondary HT due to a pheochromocytoma in a 15-year-old patient, whose metanephrine assay confirmed the diagnosis, and abdominal ultrasound and CT localised the tumour in the adrenal gland. HT was controlled with \u03b1 and \u03b2 blockers, with posterior retroperitoneal laparoscopic surgical intervention and subsequent resolution of HT. Age and concomitant hyperparathyroidism compelled genetic testing for the exclusion of MEN 2, which was negative.<\/jats:p>","DOI":"10.1136\/bcr-2015-211184","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T11:48:38Z","timestamp":1438688918000},"page":"bcr2015211184","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Pheochromocytoma: clinical review based on a rare case in adolescence"],"prefix":"10.1136","volume":"2015","author":[{"given":"Marisa Maibel","family":"Alface","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Moniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e2ndida","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.1","unstructured":"Amadeo C , et al Diretrizes Brasileiras de Hipertens\u00e3o VI."},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.2","unstructured":"Fitzgerald PA . Adrenal medulla and paraganglia. In: Gardner DG , Shoback D , eds. Greenspan's basic and clinical endocrinology. 8th edn. New York: The McGraw-Hill Companies Inc., 2007;177\u2013187."},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.3","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1590\/S0004-27302004000500022","article-title":"Pheochromocytoma","volume":"48","author":"Pereira","year":"2004","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000251887.01885.54"},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.5","doi-asserted-by":"crossref","unstructured":"Marinov L . Pheochromocytoma during childhood\u2014a case report. 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Treatment of pheochromocytoma in adults: http:\/\/www.uptodate.com\/contents\/treatment-of-pheochromocytoma-in-adults"},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62886-6"},{"key":"2025042706543980000_2015.aug04_1.bcr2015211184.15","unstructured":"Vuguin P , Coppes M , et al . 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