{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:16Z","timestamp":1756425736045,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,9,22]]},"abstract":"<jats:p>Renal involvement in Waldenstr\u00f6m's macroglobulinaemia (WM) is very unusual when compared to multiple myeloma. We report a case of a patient who developed anuric acute kidney injury secondary to cast nephropathy, dependent on high-flux haemodialysis. Complementary study revealed the presence of blood IgM monoclonal gammopathy and a massive bone marrow lymphoplasmacytic infiltration. There were no osteolytic lesions and no clinical signs\/symptoms of hyperviscosity syndrome. The diagnosis of WM was established and a dexamethasone plus cyclophosphamide regime was started, in addition to plasmapheresis. The patient partially recovered renal function allowing haemodialysis and plasmapheresis withdrawal. He remained asymptomatic with a good response to chemotherapy and 12\u2005months after his renal function remained stable. This is a rare clinical case in which WM presented as an IgM cast nephropathy, which in turn is an extremely rare renal presentation of this equally rare haematological disorder.<\/jats:p>","DOI":"10.1136\/bcr-2015-211210","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T08:12:23Z","timestamp":1444205543000},"page":"bcr2015211210","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cast nephropathy: an extremely rare renal presentation of Waldenstr\u00f6m's macroglobulinaemia"],"prefix":"10.1136","volume":"2015","author":[{"given":"T\u00e2nia","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Nephrology, Coimbra's Hospital and University Center, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Coimbra's Hospital and University Center, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edtor","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Coimbra's Hospital and University Center, Coimbra, Portugal"},{"name":"Coimbra's Medical College, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Coimbra's Hospital and University Center, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.03.008"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-055012"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.6.1256"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.08.009"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.5","doi-asserted-by":"publisher","DOI":"10.1159\/000064299"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr730"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs041"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.9475"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1200\/JCO.2000.18.1.214","article-title":"Waldenstrom's macroglobulinemia: clinical features, complications, and management","volume":"18","author":"Dimopoulos","year":"2000","journal-title":"J Clin Oncol"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01600408"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.11","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.01.030"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.01.040183.000511"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197007162830304"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200312"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-11-200512060-00005"},{"key":"2025082722221417000_2015.oct07_1.bcr2015211210.16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-11-200512060-00013"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-211210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:22:22Z","timestamp":1756358542000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-211210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":16,"alternative-id":["10.1136\/bcr-2015-211210"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-211210","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}