{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:05:37Z","timestamp":1770818737956,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,8,4]]},"abstract":"<jats:p>Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is caused by genetic alteration produced by a mutation in the \u2018patched\u2019 tumour suppressor gene, and is inherited in a dominant autosomal way. Although sporadic cases have been found, this syndrome has rarely been reported in twin patients. The syndrome is characterised by a wide range of developmental abnormalities and has a predisposition to neoplasms such as multiple pigmented basal cell carcinomas and keratocysts in jaws; it also has other features such as palmar and\/or plantar pits and calcification of falx cerebri. Owing to the critical oral and maxillofacial manifestations of this syndrome, it is important to recognise its characteristics in order to make a diagnosis, and to plot early preventive treatment and establish the right genetic evidence. Based on a combination of imaging, clinical and histopathological findings, we present a diagnosed case of Gorlin-Goltz syndrome in 18-year-old twin brothers. All cystic lesions were enucleated and 1\u2005year follow-up showed no recurrence.<\/jats:p>","DOI":"10.1136\/bcr-2015-211608","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T07:38:06Z","timestamp":1440142686000},"page":"bcr2015211608","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Gorlin-Goltz syndrome in twin brothers: an unusual occurrence with review of the literature"],"prefix":"10.1136","volume":"2015","author":[{"given":"Sonal","family":"Anchlia","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumit","family":"Bahl","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology, KM Shah Dental College, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipul","family":"Nagavadiya","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital, Ahmedabad, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,8,21]]},"reference":[{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.1","first-page":"116","article-title":"Gorlin-Goltz syndrome: report of two cases","volume":"2","author":"Lovekesh","year":"2014","journal-title":"Int J Sci Stud"},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.2","unstructured":"http:\/\/www.encyclopedia.com\/topic\/Twins.aspx 06-06-2015."},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.3","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi116"},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.4","first-page":"393","article-title":"Gorlin-Goltz syndrome\u2014case report","volume":"5","author":"Garg","year":"2011","journal-title":"J Clin Diagn Res"},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.5","first-page":"137","article-title":"Gorlin-Goltz syndrome: case report","volume":"1","author":"Ramesh","year":"2010","journal-title":"J Oral Health Res"},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.6","unstructured":"Rajendran R . Benign and malignant tumours of oral cavity. In: Shafer WG , Hine MK , Levy BM , eds. Shafers textbook of oral pathology. 5th edn. Noida: Elsevier Publication, 2006:142."},{"key":"2025082802065522000_2015.aug21_1.bcr2015211608.7","first-page":"E338","article-title":"Gorlin-Goltz syndrome: clinicopathologic aspects","volume":"13","author":"Ortega Garc\u00eda de Amezaga","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-211608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:07:05Z","timestamp":1756372025000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-211608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,21]]},"references-count":7,"alternative-id":["10.1136\/bcr-2015-211608"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-211608","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,21]]}}}