{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:40:04Z","timestamp":1756276804045,"version":"3.44.0"},"reference-count":4,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,1,14]]},"abstract":"<jats:p>A 10-year-old boy developed a perifollicular rash during interim maintenance of T-Cell acute lymphoblastic leukaemia. Differential diagnoses included drug reaction and inflammatory process. Before diagnosis, the patient had a limited diet\u2014low in vegetables and fruits\u2014due to selective eating, with later anorexia and taste aversions due to chemotherapy treatment. Despite nutritional counselling and starting a multivitamin, the patient incurred severe weight loss (18.5% of his usual body weight). Serum levels of ascorbic acid were non-detectable, at &lt;5\u2005\u03bcmol\/L, indicative of vitamin C deficiency. The patient began vitamin C supplementation containing 125\u2005mg ascorbic acid three times a day for 7\u2005days, then 125\u2005mg once daily for 3\u2005months to normalise serum vitamin C. After ascorbic acid treatment was completed, the patient started a complete multivitamin and made efforts to eat fruits and vegetables rich in vitamin C. His serum ascorbic acid concentrations normalised to 52\u2005\u03bcmol\/L 3\u2005months after receiving supplementation.<\/jats:p>","DOI":"10.1136\/bcr-2015-212090","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T11:30:21Z","timestamp":1453980621000},"page":"bcr2015212090","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Severe vitamin C deficiency in a child newly diagnosed with T-cell ALL due to nutrient gap"],"prefix":"10.1136","volume":"2016","author":[{"given":"Sydney","family":"Harris-Janz","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Halton","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"2025082623223548000_2016.jan28_1.bcr2015212090.1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.e55"},{"key":"2025082623223548000_2016.jan28_1.bcr2015212090.2","doi-asserted-by":"crossref","first-page":"717518","DOI":"10.1155\/2010\/717518","article-title":"Infantile scurvy: two case reports","volume":"2010","author":"Ghedira Besbes","year":"2010","journal-title":"Int J Pediatr"},{"key":"2025082623223548000_2016.jan28_1.bcr2015212090.3","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708020-00006"},{"key":"2025082623223548000_2016.jan28_1.bcr2015212090.4","first-page":"415","article-title":"Anthropometric and biochemical assessment of nutritional status in pediatric cancer patients","volume":"32","author":"\u0130lhan","year":"2015","journal-title":"Pediatr Hematol Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-212090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:22:44Z","timestamp":1756275764000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-212090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,28]]},"references-count":4,"alternative-id":["10.1136\/bcr-2015-212090"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-212090","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,1,28]]}}}