{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:04:27Z","timestamp":1756339467965,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,10,31]]},"abstract":"<jats:p>Giant prolactinomas are rare pituitary tumours of which management can be a challenge. A 28-year-old man presented with headaches, visual impairment and behavioural changes. Clinically, the patient was found to have hypogonadism and bitemporal hemianopsia. A MRI demonstrated a pituitary tumour 76\u2005mm in diameter and blood tests revealed a serum prolactin of 158\u2005700\u2005\u00b5U\/mL (reference range 58\u2013254). Initially, a craniotomy was performed. Immunohistochemistry of the tumour identified a prolactinoma with a high proliferative index and the patient was started on treatment with a dopamine agonist. A year later, neurological symptoms worsened due to regrowth of the lesion's cystic component, and so further surgery was performed. After 10\u2005years of treatment with dopamine agonists, the prolactin levels decreased by 96.8%, there was an effective reduction in tumour size, and the neurological signs and symptoms resolved.<\/jats:p>","DOI":"10.1136\/bcr-2015-212221","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T09:38:32Z","timestamp":1448012312000},"page":"bcr2015212221","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Ten-year follow-up of a giant prolactinoma"],"prefix":"10.1136","volume":"2015","author":[{"given":"Vera","family":"Fernandes","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital de Braga, Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Joana","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital de Braga, Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Braga, Braga, Portugal"},{"name":"Department of Pituitary Tumours Group, Hospital de Braga, Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olinda","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital de Braga, Braga, Portugal"},{"name":"Department of Pituitary Tumours Group, Hospital de Braga, Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0013"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.2.0299"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.3","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12242"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.4","first-page":"140020","article-title":"Delayed presentation of late-onset cerebrospinal fluid rhinorrhoea following dopamine agonist therapy for giant prolactinoma","volume":"2014","author":"Prague","year":"2014","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90668-1"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.6","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0588-3"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.7","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.5.874"},{"key":"2025082707333112000_2015.nov20_1.bcr2015212221.8","unstructured":"Javorsky BR , Aron DC , Findling JW , et al . 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